Clinical Fundamentals for Radiation Oncologists

Forewords
Preface
Contributing Authors
Reviewers
Part I: Basic Science Of Radiation Oncology
Radiation Physics, Dosimetry, and Treatment Planning - Allan Caggiano, M.S.
The Physics of Radiation Oncology
Radioactive Decay
Electromagnetic Radiation and Properties of Interaction
Particulate Radiation Properties and Interactions
The Physics of Dosimetry
The Physics of Radiation Treatment Planning and Delivery
Brachytherapy
Other Radiation Therapy Modalities
References
Radiation Biology - Richard C. Miller, M.D., and Jimmy J. Caudell, M.D, Ph.D.
Radiobiological Quantities
Radiation Effects on DNA and Chromosomes
Normal Tissues Kinetics and Proliferation Status
Early and Late Reacting Tissues: Specific Organs
References
Molecular Radiobiology - Jimmy J. Caudell, M.D, Ph.D., and Richard C. Miller, M.D.
Molecular Biology Techniques
Cell Cycle
Oncogenes
Tumor Suppressor Genes
Therapeutics
Apoptosis
Angiogenesis
Carcinogenesis and Metastasis
References
Radiation Protection for Radiation Oncology - Allan Caggiano, M.S.
Measurement of Radiation Quantities
Radiation Protection Principles
Organizations
Regulations
Occupational and General Public Dose Limits
Radiation-Induced Biological Effects
Treatment Room Design
Signage and Labeling Requirements
Equipment and Area Monitoring
Personnel Monitoring
References
Statistical Considerations in Radiation Oncology and Clinical Trials - David D. Smith, Ph.D., and Timothy E. Schultheiss, Ph.D.
Definition of Statistical Terms
Model Fitting
Survival Analysis and Its Pitfalls
Logistic Regression and Its Pitfalls
Proportional Hazards and Their Pitfalls
Retrospective Studies and Their Pitfalls
Meta-Analysis and Its Pitfalls
Conclusions
Bibliography
Part II: Clinical Radiation Oncology
Skin Cancers
Non-Melanoma
Melanoma
Annotated Bibliography
Primary Brain Cancers
Low-Grade Glioma
High-Grade Glioma
Brainstem Glioma
Optic Glioma
Ependymoma
Meningioma
Medulloblastoma
Pineal-Gland Tumor
Pituitary Adenoma
Annotated Bibliography
Head and Neck Cancers
Oral Cavity Cancer
Oropharyngeal Cancer
Nasopharyngeal Cancer
Hypopharyngeal Cancer
Laryngeal Cancer
Nasal Cavity and Paranasal Sinuses Tumor
Parotid Gland Tumor
Unknown Primary Tumor
Annotated Bibliography
Breast Cancers
Non-Invasive Breast Cancer
Early Stage Breast Cancer
Post Mastectomy Radiation Therapy
Locally Advanced Breast Cancer
Inflammatory Breast Cancer
Recurrent Breast Cancer
Annotated Bibliography
Thoracic Cancers
Non-Small-Cell Lung Cancer
Superior Sulcus Tumors
Medically Inoperable NSCLC
Small-Cell Lung Cancer
Thymoma
Annotated Bibliography
Gastrointestinal Cancers
Esophageal Cancer
Gastric Cancer
Pancreatic Cancer
Colon Cancer
Rectal Cancer
Anal Cancer
Annotated Bibliography
Genitourinary Cancers
Renal Cancer
Bladder Cancer
Prostate Cancer
Testicular Cancer
Annotated Bibliography
Gynecological Cancers
Endometrial Cancer
Cervical Cancer
Ovarian Cancer
Vaginal Cancer
Vulvar Cancer
Annotated Bibliography
Lymphoma and Hematologic Cancers
Hodgkin's Lymphoma
Non-Hodgkin's Lymphoma
Annotated Bibliography
Sarcomas
Soft-Tissue Sarcomas
Annotated Bibliography
Pediatric Cancers
Acute Lymphoblastic Leukemia
Hodgkin's Disease
Neuroblastoma
Wilms' Tumor (Nephroblastoma)
Rhabdomyosarcoma (RMS)
Ewing's Sarcoma
Retinoblastoma
Annotated Bibliography
Part III: Palliative Care And Complications
Palliation of Metastatic Cancers
Metastatic Brain Cancer
Spinal Cord Compression
Superior Vena Cava (SVC) Syndrome
Metastatic Bone Cancers
Annotated Bibliography
Treatment Side Effects and Their Management
Normal Tissue Tolerance to Therapeutic Irradiation
Skin
Radiation Fibrosis and Muscle Relaxants
Pain Management
Nervous System
Psychotropic Medications
Head and Neck
Breast
Thorax
Gastrointestinal Tract
Genitourinary
Gynecological
Common Toxicity (Side Effect) Criteria (CTC)
References
Acronyms and Abbreviations
Clinical Bibliography
Index
About the Author