Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields

Michael D. Morris is professor of chemistry at the University of Michigan and an affiliated member of the university's Biomedical Engineering faculty, its Comprehensive Cancer Center and its Core Center for Musculoskeletal Research. He presently serves on the editorial boards of Applied Spectroscopy, Journal of Biomedical Optics and Calcified Tissue International. His honors include the ACS Division of Analytical Chemistry Award in Spectrochemical Analysis, the Anachem Award, the Society for Applied Spectroscopy New York Section Gold Medal and Meggers Award, the Mann Award in Applied Raman Spectroscopy, and several University of Michigan awards. His research interests include Raman spectroscopy and Raman imaging. He is a pioneer in the analytical applications of Raman spectroscopy, particularly in its uses in microscopy and imaging. He has made important contributions to Raman spectroscopic instrumentation based on holographic and liquid crystal optics and has been a leader in development of computational techniques for multivariate Raman image processing and three-dimensional Raman imaging. In the last several years his laboratory has led the development of Raman spectroscopy for study of musculoskeletal tissues. He and his co-workers have published on bone biomechanics, structure/function relationships in mouse models for genetic disorders, mechanisms of tissue mineralization and non-invasive spectroscopic assessment of bone quality.

1. Lasers, spectrographs and detectors.- 2. Fiber optic Raman probes for biomedical and pharmaceutical applications.- 3. Deep layer tissue and powder spectroscopy: SORS and transmission Raman.- 4. SERS and its applications to biological samples.- 5. Raman, mapping, imaging and tomography.- 6. Coherent Raman scattering microscopy.- 7. Raman optical activity (ROA).- 8. Chemometrics.- 9. Discovery and formulation.- 10. Raman spectroscopy: a strategic tool in the process analytical technology toolbox.- 11. Emerging dental applications of Raman spectroscopy.- 12. Raman spectroscopy of ocular tissues.- 13. Raman spectroscopy for early cancer detection, diagnosis and elucidation of disease specific biochemical changes.- 14. Raman spectroscopy of bone and cartilage.- 15. Vibrational microscopic imaging of skin: applications to drug delivery, single cell biochemistry and wound healing.- 16. Raman spectroscopy of blood and urine specimens.- 17. Quantitative Raman and fluorescence spectroscopy of artificial hip prostheses.- 18. Raman spectroscopy: a tool for tissue engineering.- 19. Biomedical and pharmaceutical applications of Raman spectroscopy.- 20. Future directions.