Genetic Breakthroughs-- Their Implications for You and Your Health (Collection)
Addison Wesley
978-0-13-303963-4 (ISBN)
These three cutting-edge books reveal how modern genetics has already transformed the world – and will transform it again and again in the coming years. Mobile DNA book thoroughly reviews our current scientific understanding of the significant role that mobile genetic elements play in the evolution and function of genomes and organisms–from plants and animals to humans. Renowned geneticist Haig Kazazian offers an accessible intellectual history of the field’s research strategies and concerns, explaining how advances have opened up new questions, and how new tools and capabilities have encouraged still more progress. He introduces today’s key strategies for advancing the field, and previews long-term research strategies that may lead to even deeper insights. Next, in Investigating the Human Genome, leading medical genetics scholar Moyra Smith reviews current and recent work in genetics and genomics to assess progress in understanding human variation and the pathogenesis of common and rare diseases linked to genetics. You’ll discover how these advances are shedding new light on issues ranging from human origins to psychiatric disease, Alzheimer’s to epigenetics. Finally, in Genes, Chromosomes, and Disease, Nicholas Wright Gillham offers an exceptionally readable overview of the rise and transformations of medical genetics – and of the eugenic impulses that it has inspired.
From world-renowned leaders and experts, including Haig H. Kazazian, Moyra Smith, and Nicholas Wright Gillham
Haig H. Kazazian spent 25 years on the Johns Hopkins faculty before joining the University of Pennsylvania School of Medicine as Chair of the Department of Genetics in 1994. In July 2010, he returned to Johns Hopkins as Professor in the Institute of Genetic Medicine. Still heavily involved in molecular genetic research, he has concentrated for 20 years on mammalian and human transposable elements (“jumping genes”). A member of the Institute of Medicine of the National Academy of Sciences and the American Academy of Arts and Sciences, he was awarded the 2008 William Allan Award, the top honor of the American Society of Human Genetics. Moyra Smith is Professor of Pediatrics and Human Genetics at the School of Medicine at University of California, Irvine. A leading scholar in her field, she has served as an editor of McKusick’s classic “Red Book,” Mendelian Inheritance in Man, and has written several monographs in the Oxford Series on Human Genetics. Nicholas Wright Gillham is James B. Duke Professor of Biology emeritus at Duke University. A leading expert on the genetics of cellular organelles, he has a longstanding interest in the history of science. He taught Duke’s innovative course “The Social Implications of Genetics.”
Mobile DNA: Finding Treasure in Junk
Preface: Thoughts on Doing Science xii
Chapter 1 Introduction to Mobile DNA 1
Chapter 2 Varieties of Mobile DNA 5
Chapter 3 DNA Transposons 19
Chapter 4 Mobile DNA of Model Organisms 29
Chapter 5 Exceptional Scientists Working on Mobile DNA in Lower Organisms 35
Chapter 6 Role of Bioinformatics in Genome Analysis 43
Chapter 7 The Prologue 49
Chapter 8 “Welcome to the Wonderful World of LINEs” 59
Chapter 9 An Experimental Breakthrough 73
Chapter 10 Reverse Transcriptase to the Rescue 81
Chapter 11 A Quirk of L1 Elements–A Lousy 3’ End Is Important for Genome Evolution 85
Chapter 12 A Tour de Force from Tom Eickbush 89
Chapter 13 “I don’t believe all those colonies represent retrotransposition events.” 93
Chapter 14 L1 Encodes an Endonuclease 101
Chapter 15 The Jocks 105
Chapter 16 The Mayor and the Frenchman 115
Chapter 17 Ostertag’s Coups 121
Chapter 18 The Independent Canadian 133
Chapter 19 The Musician Scientist 141
Chapter 20 Young Ladies in the Back Bay 145
Chapter 21 The Brilliant Young Lady from China 157
Chapter 22 Hiroki’s Big Surprises 163
Chapter 23 A Young Man with a Purpose 173
Chapter 24 Other Mobile DNA in Mammalian Genomes 179
Chapter 25 Effects of Retrotransposons on Mammalian Genomes 187
Chapter 26 Host Factors Involved in L1 Retrotransposition 201
Chapter 27 Why Mobile DNA? 207
Chapter 28 The Future of Mobile DNA Research 209
Chapter 29 Predictions for Mobile DNA 221
References 225
Glossary 249
Index 255
Investigating the Human Genome: Insights into Human Variation and Disease Susceptibility
Preface vii
Chapter 1 Genome Architecture and Sequence Variation in Health and Disease 1
Chapter 2 Genes and Transcripts: Insight into Regulation at Different Levels 23
Chapter 3 Epigenetics: Modifications of DNA, Chromatin, and Gene Expression 37
Chapter 4 Gene Environment Interactions 53
Chapter 5 Pathways, Phenotypes, and Phenocopies 67
Chapter 6 Dynamic Function, Synaptic Activity, and Plasticity 81
Chapter 7 Late Onset Neurodegenerative Diseases 101
Chapter 8 Genes and Genomes in Cancer: Targeted Therapies 131
Chapter 9 Functional Genomics: Personalized Medicine and Therapeutics 153
Epilogue 167
References 171
About the Author 203
Index 205
Genes, Chromosomes, and Disease: From Simple Traits, to Complex Traits, to Personalized Medicine
Preface ix
Chapter 1: Hunting for disease genes 1
Chapter 2: How genetic diseases arise 25
Chapter 3: Ethnicity and genetic disease 55
Chapter 4: Susceptibility genes and risk factors 81
Chapter 5: Genes and cancer 103
Chapter 6: Genes and behavior 129
Chapter 7: Genes and IQ: an unfinished story 151
Chapter 8: Preventing genetic disease 175
Chapter 9: Treating genetic disease 199
Chapter 10: The dawn of personalized medicine 235
Postscript: a cautionary note 249
References and notes 253
Glossary 293
Some useful human genetics Web sites 307
Acknowledgments 309
About the author 311
Index 313
| Erscheint lt. Verlag | 27.2.2012 |
|---|---|
| Verlagsort | Boston |
| Sprache | englisch |
| Gewicht | 1 g |
| Themenwelt | Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik |
| Naturwissenschaften | |
| ISBN-10 | 0-13-303963-3 / 0133039633 |
| ISBN-13 | 978-0-13-303963-4 / 9780133039634 |
| Zustand | Neuware |
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