Biomedical Applications of Peptide-, Glyco- and Glycopeptide Dendrimers, and Analogous Dendrimeric Structures

Introduction.- Chemistry and struture to dendrimers: Definition of terms and nomenclature.- Sugar code (glyco code).- Classes of peptide-, glyco, and glycopeptide dendrimers.- The dendritic state and dendritic effects.- Synthesis of dendrimers: convergent and divergent approaches.- Purification and characterization of dendrimers.- Dendrimeric libraries.- Dendrimers in catalysis.-Dendrimers and their biological and therapeutic applications: Dendrimers and solubility.- Biocompability and toxicity of dendrimers.- Dendrimers in nanoscience and nanotechnology.- Dendrimers in drug delivery.- Dendrimers in gene delivery.-Dendrimers and bacteria.- Dendrimers and viruses.- Dendrimers and parasites.- Cancer.- Diagnostics, lectin detection and cell-cell interactions.- Dendrimers as biosensors and imaging tools.- Dendrimers regulating in intracellular signaling pathways.- Vaccines and immunomodulation.- Dendrimers in neurodegenerative diseases.- Conclusions and persperctives.