Sperm Chromatin (eBook)
XXII, 512 Seiten
Springer New York (Verlag)
978-1-4419-6857-9 (ISBN)
Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.
Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.
I. Human Sperm Chromatin: Structure and Function1. Sperm Chromatin: An Overview Rodney Balhorn2. Spermatogenesis: An Overview Rakesh Sharma and Ashok Agarwal3. Sperm NucleoproteinsRafael Oliva and Judit Castillo4. The Relationship Between Chromatin Structure and DNA Damage in Mammalian SpermatozoaKenneth Dominguez, Chris D. R. Arca, and W. Steven Ward5. Chromosome Positioning in SpermatozoaAndrei Zalensky, Olga Mudrak, and Irina Zalenskaya 6. Sperm Mitochondrial DNAJustin C. St. John and Bianca St. John7. The Sperm EpigenomeDonovan Chan and Jacquetta Trasler 8. RNA Expression in Germ Cells During Spermatogenesis (Germ Cell Transcriptome) Tin-Lap Lee, Albert Hoi-Hung Cheung, Owen M. Rennert, and Wai-Yee ChanII. Laboratory Evaluation of Sperm Chromatin9. Sperm Chromatin Structure Assay (SCSA®): 30 Years’ Experience with the SCSA®Donald P. Evenson 10. Sperm Chromatin Dispersion Test: Technical Aspects and Clinical ApplicationsJaime Gosálvez, Carmen López-Fernández, and José Luís Fernández 11. Basic and Clinical Aspects of the Sperm Chromomycin A3 Assay Giancarlo Manicardi, Davide Bizzaro, and Denny Sakkas12. Cytochemical Tests for Sperm Chromatin MaturityIgor Tsarev and Juris Erenpreiss 13. Acridine Orange Test for Assessment of Human Sperm DNA IntegrityAlex C. Varghese, C. Fischer–Hammadeh, and M. E. Hammadeh 14. Laboratory Evaluation of Sperm Chromatin: TUNEL AssayRakesh Sharma and Ashok Agarwal15. The Basic and Clinical Aspects of the Sperm Comet AssayLuke Simon and Sheena E. M. Lewis16. Assays Used in the Study of Sperm Nuclear ProteinsTimothy G. Jenkins, Benjamin R. Emery, and Douglas T. Carrell17. Sperm Epigenetic ProfileCristina Joana Marques, Alberto Barros, and Mário Sousa18. Clinical Significance of Sperm RNAJean-Pierre Dadoune, Isabelle Galeraud-Denis, and Serge Carreau III. Biological and Clinical Determinants of Sperm Chromatin Damage19. Role of Oxidative Stress in the Etiology of Sperm DNA DamageR. John Aitken and Geoffry N. De Iuliis20. Abortive Apoptosis and Sperm Chromatin DamageHasan M. El-Fakahany and Denny Sakkas21. Spermiogenesis in Sperm Genetic IntegrityMarie-Chantal Grégoire, Frédéric Leduc, and Guylain Boissonneault22. Male Subfertility and Sperm Chromatin DamageMona Bungum, Aleksander Giwercman, and Marcello Spanò 23. Aging and Sperm DNA DamageFábio F. Pasqualotto and Eleonora B. Pasqualotto24. Cancer in Males: Implications for Sperm Quality, Fertility, and Progeny OutcomePeter Chan and Bernard Robaire25. Sperm Chromatin and Environmental FactorsAleksander Giwercman26. Effects of Male Accessory Gland Infection on Sperm ParametersAldo E. Calogero, Sandro La Vignera, Rosita A. Condorelli, Rosario D’Agata, and Enzo VicariIV. Sperm Chromatin and Assisted Reproductive Technology Outcomes27. The Impact of Sperm Processing and Cryopreservation on Sperm DNA IntegrityDan Yu, Luke Simon, and Sheena E. M. Lewis28. Structure of Chromatin in Human Sperm Bound to Hyaluronic Acid: The Benefits of PICSI Dish Mediated Sperm SelectionLeyla Sati and Gabor Huszar29. Electrophoretic Sperm SeparationSteven Fleming and R. John Aitken30. Antioxidants and Sperm DNA DamageArmand Zini and Maria San Gabriel31. Sperm Chromatin and ART (IUI, IVF, and ICSI) PregnancyMona Bungum32. Sperm DNA Damage and Pregnancy Loss After IVF/ICSIArmand Zini and Jason Matthew Boman33. Postnatal Effects of Sperm Chromatin DamageMiriam Pérez-Crespo, Raúl Fernández-González, Miguel Ángel Ramírez, Eva Pericuesta, Alexandra Calle, and Alfonso Gutiérrez-Adán34. Evaluation of Chromatin and DNA Integrity in Testicular Sperm Armand Zini and Naif Al-HathalV. Protocols and Integrity Tests35. The Alkaline Comet AssaySheena E. M. Lewis 36. Sperm Chromatin Structure Assay (SCSA)Donald P. Evenson 37. Measurement of DNA Damage in Spermatozoa by TUNEL AssayRakesh Sharma and Ashok Agarwal38. Clinical Utility of Sperm DNA Integrity TestsArmand Zini
| Erscheint lt. Verlag | 4.8.2011 |
|---|---|
| Zusatzinfo | XXII, 512 p. 77 illus., 48 illus. in color. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Gynäkologie / Geburtshilfe |
| Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie | |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Urologie | |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Naturwissenschaften ► Biologie | |
| Technik | |
| Schlagworte | Assisted Reproductive Technologies • Chromatin • DNA • DNA repair • Histones • Male gamete morphogenesis • male infertility • Nucleoproteins • Protamine • Sperm • Spermatogenesis • Sperm Epigenome • Testis |
| ISBN-10 | 1-4419-6857-1 / 1441968571 |
| ISBN-13 | 978-1-4419-6857-9 / 9781441968579 |
| Haben Sie eine Frage zum Produkt? |
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