Recent Developments in Biomolecular NMR

Dr Marius Clore's career began at University College London where he studied for his BSc in Biochemistry, moving to University College Hospital Medical School he became an MD and finally a PhD at the National Institute for Medical Research, London. In 1984, he became head of the Biological NMR Group at Max-Planck Institute for Biochemistry and then moved in 1988 to NIH, USA. He is currently an NIH Distinguished Investigator and Chief of the Protein Nuclear Magnetic Resonance Section and has made many pioneering contributions in the development of NMR spectroscopy for structural characterization of biological macromolecules. Dr Clore has been awarded numerous prizes and honours and was ranked in the top 20 in h-index ranking of living chemists in 2009. He is also a 3rd Degree black belt in Tae Kwon Do. Dr Jennifer Potts studied at the University of Sydney before becoming a postdoctoral fellow at the University of Oxford in 1992. Staying at Oxford until 2005 as a research associate and latterly lecturer in biochemistry, she then became Anniversary Reader at the University of York where her recent work has been on fibronectin recognition domains which fold on experiencing their target.

Isotope-labelling of Methyl Groups for NMR Studies of Large Proteins;

Low y-nuclei detection experiments for biomolecular NMR;

Making the most of chemical shifts;

Protein Structure Determination using sparse NMR data;

NMR Studies of Disordered but Functional Proteins;

Paramagnetic NMR Spectroscopy and Lowly Populated States;

NMR Relaxation Dispersion Studies of Large Enzymes in Solution;

Residual Dipolar Couplings as a Tool for the Study of Protein Conformation and Conformational Flexibility;

Characterizing RNA Dynamics using NMR Residual Dipolar Couplings;

Non-canonical ligand-binding events as detected by NMR;

Advances in Biomolecular NMR for Drug Discovery;

NMR of membrane proteins;

Recent Developments in Biomolecular Solid-state NMR;

Subject Index