Toll-like Receptors: Roles in Infection and Neuropathology -

Toll-like Receptors: Roles in Infection and Neuropathology

Tammy Kielian (Herausgeber)

Buch | Softcover
XI, 191 Seiten
2012 | 2009
Springer Berlin (Verlag)
978-3-642-26911-0 (ISBN)
160,49 inkl. MwSt
This book highlights traditional roles for TLRs in infectious diseases of the CNS. It also discusses recently emerging roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands.
Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled "Toll-like receptors: Roles in Infection and Neuropathology". The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second half of the volume discusses recently emerging roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands. Several conceptual theories are introduced in various chapters that deal with the dual nature of TLR engagement and whether these signals favor neuroprotective versus neurodegenerative outcomes. This volume should be informative for both experts as well as newcomers to the field of TLRs in the nervous system based on its coverage of basic TLR biology as well as specialization to discuss specific diseases of the nervous system where TLR function has been implicated. A must read for researchers interested in the dual role of these receptors in neuroinfection and neurodegeneration.

Preface.- Overview of Toll-like Receptors (TLRs) in the CNS.- Toll-like receptors in Bacterial Meningitis.- Toll-like receptors (TLRs) in brain abscess.- TLRs in CNS viral infections.- Toll-like receptors in CNS Parasitic Infections.- Toll-like receptors in neurodegeneration.- Toll-like receptors (TLRs) in Spinal Cord Injury.- TLRs in Alzheimer s disease.- Toll-like receptors (TLRs) in multiple sclerosis.- Toll-like receptors in Peripheral Nerve Injury and Neuropathic Pain.- Subject index.

Erscheint lt. Verlag 14.3.2012
Reihe/Serie Current Topics in Microbiology and Immunology
Zusatzinfo XI, 191 p. 8 illus. in color.
Verlagsort Berlin
Sprache englisch
Maße 155 x 235 mm
Gewicht 316 g
Themenwelt Studium Querschnittsbereiche Infektiologie / Immunologie
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Mikrobiologie / Immunologie
Schlagworte Alzheimer • Alzheimer's disease • bacterial meningitis • brain abscess • CNS parasitic infections • CNS viral infections • endogenous ligand • Infections • infectious disease • Multiple Sclerosis • nervous system • peripheral nerve injury • spinal cord injury
ISBN-10 3-642-26911-7 / 3642269117
ISBN-13 978-3-642-26911-0 / 9783642269110
Zustand Neuware
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