cGMP: Generators, Effectors and Therapeutic Implications (eBook)

Basic Generators and Effectors.- A Short History of cGMP, Guanylyl Cyclases, and cGMP-Dependent Protein Kinases.- Biochemistry of Soluble Guanylate Cyclase.- Genetic Mouse Models of the NO Receptor ‘Soluble’ Guanylyl Cyclases.- Function and Dysfunction of Mammalian Membrane Guanylyl Cyclase Receptors: Lessons from Genetic Mouse Models and Implications for Human Diseases.- Phosphodiesterases in the Central Nervous System.- Structural and Biochemical Aspects of Tandem GAF Domains.- Cyclic Nucleotide-Gated Channels.- cGMP Regulated Protein Kinases (cGK).- cGK Substrates.- Biochemical Detection of cGMP From Past to Present: An Overview.- Novel Techniques for Real-Time Monitoring of cGMP in Living Cells.- Pharmacology of cGMP.- NO and sGC-Stimulating NO Donors.- NO-Independent, Haem-Dependent Soluble Guanylate Cyclase Stimulators.- NO- and Haem-Independent Soluble Guanylate Cyclase Activators.- Natriuretic Peptides: Their Structures, Receptors, Physiologic Functions and Therapeutic Applications.- Cyclic GMP-Hydrolyzing Phosphodiesterases.- cGMP-Dependent Protein Kinase Modulators.- cGMP-Dependent Protein Kinase as a Modifier of Behaviour.- Clinical Applications.- cGMP in the Vasculature.- Modulating cGMP to Treat Lung Diseases.- Modulation of cGMP in Heart Failure: A New Therapeutic Paradigm.- Erectile Dysfunction and Lower Urinary Tract.- cGMP and cGMP-Dependent Protein Kinase in Platelets and Blood Cells.- cGMP Signalling in the Mammalian Brain: Role in Synaptic Plasticity and Behaviour.