Molecular Chaperones in Health and Disease (eBook)

Part 1: Molecular Mechanisms of Chaperone Action and Heat Shock Response.- Chaperones in Preventing Protein Denaturation in Living Cells and Protecting Against Cellular Stress. Feedback Regulation of the Heat Shock Response. Protein Folding in the ER and the Unfolded Protein Response.- Part 2: Role of Chaperones and HSFs in Cell Signalling and Development.- Molecular Chaperones in Signal Transduction. Chaperoning of Glucocorticoid Receptors. Heat Shock Response : Lessons from Mouse Knockouts. HSFs in Development. Heat Shock Proteins: Endogenous Modulators of Apoptotic Cell Death . Part 3: Chaperones in Disease.- Protein Aggregation as a Cause for Disease. The Role of Chaperones in Parkinson’s Disease and Prion Diseases. Chaperoning Oncogenes: Hsp90 as a Target of Geldanamycin.- Part 4: Potential Applications of Chaperones.- Heat Shock Proteins in Immunity. Molecular Chaperones in Cancer Immunotherapy. Hsp90 Inhibitors in the Clinic. Pharmacological Targeting of Catalyzed Protein Folding: The Example of Peptide Bond cis/trans Isomerases. Chemical, Pharmacological and Other Small-Molecule Chaperones - Mechanism of Action and Potential Use. Pharmacological Modulation of the Heat Shock Response.