Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases (eBook)
XXVI, 395 Seiten
Springer US (Verlag)
978-0-387-23695-7 (ISBN)
As our understanding of apoptotic pathway expands, we are coming to realize the great potential of utilizing this pathway to treat diseases such as cancer. The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients. Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways. The reader by the end of the book should have greater insight into the understanding and utilization of apoptotic pathways to fight diseases such as cancer.
As our understanding of apoptotic pathway expands, we are coming to realize the great potential of utilizing this pathway to treat diseases such as cancer. The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients. Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways. The reader by the end of the book should have greater insight into the understanding and utilization of apoptotic pathways to fight diseases such as cancer.
Chapter I: Apoptotic Pathways and Their Regulation Chapter II: Mechanisms of Anticancer Drug Action Chapter III: Death Receptor Pathways as Targets For Anticancer Therapy Chapter IV: Caspases; Modulators of Apoptosis and Cytokine Maturation – Targets For Novel Therapies Chapter V: The Intrinsic (Mitochondrial) Death Pathway and New Cancer Therapeutics: BCL-2 Family In Focus Chapter VI: Survivin, Other OAPS, SMAC/DIABLE, and OMI/HTRA2 – Modulation of the Advancing Apoptotic Process Chapter VII: The Life Cycle of p52: A Key Target in Drug Development Chapter VIII: Growth Factors, Receptors, and Kinases: Their Exploration To Target Cancer Chapter IX: Targets For Apoptotic Intervention in Rheumatoid Arthritis Chapter X: Therapeutic Inhibition of Apoptotis Caused By Stroke Chapter XI: Monoclonal and Bispecific Antibodies as Novel Therapeutics Chapter XII: Targeting the Proteasome in Cancer Therapy Chapter XIII: D-RNA i-Based Therapeutics Chapter XIV: Nuclear Transcription Factor – kB: A Drug Target For All Seasons Chapter XV: Monitoring of Programmed Cell Death In Vivo and In Vitro, - New and Old Methods of Cancer Therapy Assessment Chapter XVI: Current Strategies In Tumor-Targeting Chapter XVII: Strategies of Protection of Normal Cells During Chemo- and Radio- Therapy Based On Modulation of Cell Cycle and Apoptotic Pathways Summary Table: New Therapeutic Agents Designed By Exploring the Recent Progress On Our Understanding of Cell Death Pathways
| Erscheint lt. Verlag | 20.6.2006 |
|---|---|
| Zusatzinfo | XXVI, 395 p. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Medizin / Pharmazie ► Pharmazie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Studium ► Querschnittsbereiche ► Infektiologie / Immunologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| Technik | |
| Schlagworte | Antibody • Apoptosis • Cancer • Cancer Therapy • Cell • cell cycle • cell death • Cytokine • Development • Diseases • mitochondria • Programmed Cell Death • Regulation • transcription • Vivo |
| ISBN-10 | 0-387-23695-3 / 0387236953 |
| ISBN-13 | 978-0-387-23695-7 / 9780387236957 |
| Haben Sie eine Frage zum Produkt? |
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