Chemistry and Biology

Chemistry and Biology (eBook)

eBook Download: PDF
1998 | 1. Auflage
391 Seiten
Elsevier Science (Verlag)
978-0-08-086576-8 (ISBN)
Systemvoraussetzungen
192,31 inkl. MwSt
  • Download sofort lieferbar
  • Zahlungsarten anzeigen
Alkaloids are a major group of natural products derived from a variety of organisms, which are widely used as medicinal and biological agents. This Series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, this Series, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals.

Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this Series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Biology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

Key Features
* Indispensable reference work written by leading experts in the field
* Provides up-to-date, timely reviews on compounds and classes of great interest
* Covers synthesis, biosynthesis, biology, as well as isolation and structure elucidation
* An essential research tool for anyone working with alkaloids from a chemical or biological perspective
Alkaloids are a major group of natural products derived from a variety of organisms, which are widely used as medicinal and biological agents. This Series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, this Series, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this Series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Biology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile. - Indispensable reference work written by leading experts in the field- Provides up-to-date, timely reviews on compounds and classes of great interest- Covers synthesis, biosynthesis, biology, as well as isolation and structure elucidation- An essential research tool for anyone working with alkaloids from a chemical or biological perspective

Cover 1
The Alkaloids, Volume 52 4
Copyright Page 5
Contents 6
Contributors 8
Preface 10
Chapter 1. Alkaloids from Sri Lankan Flora 12
I. Introduction 13
II. Surveys for Alkaloids 16
III. Quinoline Alkaloids 18
IV. Acridone Alkaloids 38
V. Isoquinoline Alkaloids 40
VI. Carbazole Alkaloids 52
VII. Monoterpene Indole Alkaloids 57
VIII. Steroidal Alkaloids 90
IX. Phenanthroindolizidine Alkaloids 92
X. Ancistrocladus Alkaloids 93
XI. Colchicine and Related Alkaloids 93
XII. Quinazoline and Quinazolone Alkaloids 95
XIII. Miscellaneous Alkaloids 95
XIV. Biological Activity 96
XV. Summary and Conclusions 107
References 108
Chapter 2. The Sarpagine Group of Indole Alkaloids 114
I. Introduction 114
II. Occurrence 116
III. Syntheses 148
IV. Reactions 156
V. Biosynthesis and Biogenesis 159
VI. Spectroscopy 162
VII. Pharmacology 197
VIII. Perspectives 197
References 198
Chapter 3. Pharmacology of Ibogaine and Ibogaine-Related Alkaloids 208
I. Introduction 208
II. Historical Overview 209
III. Chemical Structure and Properties 210
IV. Pharmacokinetics 212
V. General Pharmacological Actions 213
VI. Lethality and Neurotoxic Effects 222
VII. Effects on Specific Neurotransmitter Systems 224
VIII. Conclusions 235
References 237
Chapter 4. Chemistry and Biology of Steroidal Alkaloids from Marine Organisms 244
I. Introduction 244
II. Monomeric Steroidal Alkaloids 245
III. Dimeric Steroidal Alkaloids 250
IV. Steroidal Amines from Marine Organisms 259
V. Synthetic Studies 261
VI. Biogenesis 265
VII. Pharmacology 266
VIII. Spectroscopy 270
References 270
Chapter 5. The Monoterpene Alkaloids 272
I. Introduction 272
II. Isolation and Structure Elucidation 273
III. Synthesis and Semisynthesis 319
IV. Physical and Spectral Properties 366
V. Biosynthesis and Biogenesis 369
VI. Pharmacology 376
References 381
Cumulative Index of Titles 388
Index 398

XV Summary and Conclusions


Table VI summarizes the alkaloids encountered in the Sri Lankan flora, together with the classes to which they belong and the plant and its part from which each alkaloid was isolated. A total of 43 plant species, including 13 endemic species, yielded alkaloids (Table IV). From these 197 alkaloids were isolated, and 51 were found to be new (Table VI). The structures of most of the new alkaloids were elucidated by modern spectroscopic techniques, including 2D NMR methods. Except for 8-hydroxyquinoline-4-carbaldehyde (1), artabotrine (50), 8-methoxyouregidione (51), cyathocaline (53), koenoline (64), and monogagaine (181), the new bases have not been evaluated for their biological activity.

Table VI

Alphabetical List of the Alkaloids Encountered in Sri Lankan Flora

O-Acetylvellesamine (98) Indole Tabemaemontana dichotoma Fr 81
Actinodaphnine (27) Aporphine Litsea gardneri Bk 41
Ajmalicine (80) Indole Petchia ceylanica Lf 74
Uncaria elliptica PI 72,73
Akuammigine N-oxide (95) Indole Mitragyna parvifolia Lf 80
Alstomacrocine (112)b Indole Alstonia macrophylla Lf 84
(+)-Alstonamide (146)b Indole Alstonia macrophylla Lf 86,95
Alstonerine (Demethoxyalstophylline) (111) Indole Alstonia macrophylla Bk, Fr, Rt 79,82,88
Alstophylline (110) Indole Alstonia macrophylla Bk, Lf, Rt 82,88
Alstopicralamine (106)b Indole Alstonia macrophylla Lf 85
Alstoumerine (107)b Indole Alstonia macrophylla Lf 86
Alstozine N-oxide (104) Indole Alstonia macrophylla Lf 83
Ancistrocladine (206) Ancistrocladus Ancistrocladus hamatus Rt 117
Anhydromacralstonine (189) Indole Alstonia macrophylla Bk, Lf 82
(—)-Apparicine (96) Indole Tabemaemontana dichotoma Fr, Lf 81
Arborine (214) Quinazolone Glycosmis bilocularis Lf 25
Arborinine (10) Acridone Glycosmis bilocularis Lf 25
Artabotrine (50)b Aporphine Artabotrys zeylanicus Bk 49
Atalanine (21)b Acridone Atalantia ceylanica Bk 33
Ataline (22)b Acridone Atalantia ceylanica Bk 33
Atherospermidine (42) Aporphine Artabotrys zeylanicus Bk 48,49
Bleekerine (84) Indole Neisosperma oppositifolia Bk 76
Broussonetine (4)b Quinoline Broussonetia zeylanica Tm 21
Cabucraline (103) Indole Alstonia macrophylla Bk, Lf 82
5α-Carboxystrictosidine (78) Indole Cinchona ledgeriana PI 70,71
Rauvolfia serpentina PI 70,71
Cleistopholine (6) Benzoquinoline Cananga odorata Bk 24
Colchicine (208) Misc. Gloriosa superba Tu 118,120,122
Conamine (193) Steroidal Holarrhena mitis Sd 113
Conessine (190) Steroidal Holarrhena mitis Bk, Sd 110,111,113
Conkurchine (194) Steroidal Holarrhena mitis Bk 111
Coronaridine (119) Indole Tabemaemontana dichotoma Bk, Fr, Sd, Rt bk 87,89
T. divaricata Bk 87
Corynanthediol (93) Indole Mitragyna parvifolia PI 80
Cryptolepine (170) Misc. indole Sida acuta PI 102
Cyathocaline (53)b Azafluorenone Cyathocalyx zeylanica Bk 50
Annona reticulata Bk 51
Demethoxyalstonamide (147)b Indole Alstonia macrophylla Lf 86
Demethoxyalstophylline (Alstonerine) (111) Indole Alstonia macrophylla Rt bk 79,82,88
Demethoxyerythratidinone (59)b Erythrina Erythrina lithosperma Lf 56,57
Nb-Demethylalstophylline oxindole (160)b Oxindole Alstonia macrophylla Lf 99
2-Demethylcolchicine (210) Misc. Gloriosa superba Tu 119
Demethylpeceyline (182)b Bisindole Petchia ceylanica Lf 105
N4-Demethyltabernamine (174) Bisindole Tabemaemontana dichotoma Bk 90,93
Des-N-methylacronycine (18) Acridone Glycosmis mauritiana Bk 32
N-Desmethylmitiphylline (199) Steroidal Holarrhena mitis Lf 112,114
Dicentrinone (47) Aporphine Xylopia championii Bk 48
Dichomine (160)b Indole Tabemaemontana dichotoma Fr, Lf 91,100
Dihydrocorynantheol (92) Indole Hunteria zeylanica Bk 78
Mitragyna parvifolia PI 80
DihydrocorynantheolN-4-oxide (94) Indole Mitragyna parvifolia PI 80
5,6-Dihydroxyarborinine (13)b Acridone Pleiospermium alatum Bk, Rt bk 30
5,6-Dimethoxyarborinine (15)b Acridone Pleiospermium alatum Bk, Rt bk 30
(+)-Eburnamenine (118) Indole Hunteria zeylanica Lf 78
Eburnamine (113) Indole Hunteria zeylanica Bk, Lf 78
19R-Epiheyneanine (127) Indole Tabemaemontana...

PDFPDF (Adobe DRM)

Kopierschutz: Adobe-DRM
Adobe-DRM ist ein Kopierschutz, der das eBook vor Mißbrauch schützen soll. Dabei wird das eBook bereits beim Download auf Ihre persönliche Adobe-ID autorisiert. Lesen können Sie das eBook dann nur auf den Geräten, welche ebenfalls auf Ihre Adobe-ID registriert sind.
Details zum Adobe-DRM

Dateiformat: PDF (Portable Document Format)
Mit einem festen Seiten­layout eignet sich die PDF besonders für Fach­bücher mit Spalten, Tabellen und Abbild­ungen. Eine PDF kann auf fast allen Geräten ange­zeigt werden, ist aber für kleine Displays (Smart­phone, eReader) nur einge­schränkt geeignet.

Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen eine Adobe-ID und die Software Adobe Digital Editions (kostenlos). Von der Benutzung der OverDrive Media Console raten wir Ihnen ab. Erfahrungsgemäß treten hier gehäuft Probleme mit dem Adobe DRM auf.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen eine Adobe-ID sowie eine kostenlose App.
Geräteliste und zusätzliche Hinweise

Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.

Mehr entdecken
aus dem Bereich
Für Klinik und Praxis

von Andreas Hufschmidt; Sebastian Rauer; Franz Xaver Glocker

eBook Download (2022)
Georg Thieme Verlag KG
144,99