Antiphospholipid Syndrome II (eBook)

Cover 1
Contents 16
Preface 6
Editor biography 8
List of Contributors 12
Part I: History and Epidemiology of the Antiphospholipid Syndrome (Editor: Ronald A. Asherson) 22
Chapter 1. Milestones in the Antiphospholipid Syndrome 24
Chapter 2. Classification and Epidemiology of the Antiphospholipid Syndrome 32
Part II: Immunology and Pathophysiology of the Antiphospholipid Syndrome (Editor: Yehuda Shoenfeld) 42
Chapter 3. Lupus Anticoagulant: Detection, Standardization and Heterogeneity 44
Chapter 4. Antibodies to Cardiolipin and other Phospholipids 50
Chapter 5. ß2-Glycoprotein I and anti-ß2-Glycoprotein I Antibodies 66
Chapter 6. Anti-Prothrombin Antibodies 80
Chapter 7. The Annexins: A Target of Antiphospholipid Antibodies 92
Chapter 8. Antiphospholipid/Endothelial Cell Interaction in the Pathogenesis of the Antiphospholipid Syndrome 100
Chapter 9. Tissue Factor, Protein C pathway and other Hemostasis Abnormalities in the Pathogenesis of the Antiphospholipid Syndrome 112
Chapter 10. Systemic Involvement in the Antiphospholipid Syndrome: Lessons from Animal Models 122
Chapter 11. Cytokines, Th1/Th2 and Adhesion Molecules in the Antiphospholipid Syndrome 128
Chapter 12. Lessons from Monoclonal Antiphospholipid Antibodies 134
Chapter 13. Immunogenetics of the Antiphospholipid Syndrome 140
Chapter 14. Pathology of the Antiphospholipid Syndrome 152
Chapter 15. Antiphospholipid Antibodies in Human and Murine Atherogenesis 158
Part III: Clinical Features in the Antiphospholipid Syndrome (Editor: Ricard Cervera) 164
Chapter 16. Thrombotic Manifestations in the Antiphospholipid Syndrome 166
Chapter 17. Neurologic Manifestations in the Antiphospholipid Syndrome 176
Chapter 18. Cardiac and Pulmonary Manifestations in the Antiphospholipid Syndrome 190
Chapter 19. Renal, Hepatic and other Intra-abdominal Manifestations in the Antiphospholipid Syndrome 210
Chapter 20. Fetal and Obstetric Manifestations and Infertility in the Antiphospholipid Syndrome 226
Chapter 21. Osteo-articular Manifestations in the Antiphospholipid Syndrome 234
Chapter 22. Ophthalmic and Otological Manifestations in the Antiphospholipid Syndrome 242
Chapter 23. Dermatologic Manifestations in the Antiphospholipid Syndrome 256
Chapter 24. Endocrine Manifestations in the Antiphospholipid Syndrome 266
Chapter 25. Hematological Abnormalities in the Antiphospholipid Syndrome 280
Chapter 26. Immunological Abnormalities in the Antiphospholipid Syndrome 292
Chapter 27. "Primary", "Secondary", "Seronegative", "Catastrophic" and other Subsets of the Antiphospholipid Syndrome 306
Chapter 28. Pediatric and Familial Antiphospholipid Syndrome 318
Chapter 29. Antiphospholipid Antibodies and Malignancies 338
Chapter 30. Antiphospholipid Antibodies and Vasculitis 352
Chapter 31. Antiphospholipid Antibodies and Infections-Drugs 364
Part IV: Management and Prognosis of the Antiphospholipid Syndrome (Editor: Jean-Charles Piette) 380
Chapter 32. Management of Thrombosis in the Antiphospholipid Syndrome 382
Chapter 33. Management of Reproductive Failure in the Antiphospholipid Syndrome 396
Chapter 34. Management of the Difficult Aspects of the Antiphospholipid Syndrome 416
Chapter 35. Course and Prognosis of the Antiphospholipid Syndrome 430
Chapter 36. Novel Perspectives in the Treatment of the Antiphospholipid Syndrome–from Anticoagulation to Immunomodulation 442
Part V: Appendix 450
Chapter 37. The Antiphospholipid Syndrome in the Internet 452
Chapter 38. A Patient's Guide to the Antiphospholipid Syndrome 458
Subject Index 466