Hedgehog-Gli Signaling in Human Disease (eBook)
XIII, 228 Seiten
Springer US (Verlag)
978-0-387-33777-7 (ISBN)
Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
Dedication 4
CONTENTS 5
PREFACE 12
How the Hedgehog Outfoxed the Crab: Interference with HEDGEHOG-GLI Signaling as Anti- Cancer Therapy? 13
The Patched Receptor: Switching On/OfFthe Hedgehog Signaling Pathway 35
Making a Morphogenetic Gradient 46
Spatial and Temporal Regulation of Hair Follicle Progenitors by Hedgehog Signaling 53
Mode of PTCHl/Ptchl-Associated Tumor Formation: Insights from Mutant Ptch1 Mice 65
Basal Cell Carcinomas, Hedgehog Signaling, and the Ptch 1+ /- Mouse 75
GLI Genes and Their Targets in Epidermal Development and Disease 86
Splitting Hairs: Dissecting the Roles of Gli Activator and Repressor Functions during Epidermal Development and Disease 98
Shh EKpression in Pulmonary Injury and Disease 131
Human Correlates of GLI3 Function 141
From Oligodactyly to Polydactyly. Role of Shh and Gli3 in Limb Morphogenesis 149
The Genetics of Indian Hedgehog 158
Sonic Hedgehog Signaling in Craniofacial Development 165
Important Role of Shh Controlling Gli3 Functions during the Dorsal- Ventral Patterning of the Telencephalon 189
Regulation of Early Events in Cell Cycle Progression by Hedgehog Signaling in CNS Development and Tumorigenesis 199
Modulating the Hedgehog Pathway in Diseases 222
Hedgehog Signaling in Endodermally Derived Tumors 227
Index 237
| Erscheint lt. Verlag | 24.6.2007 |
|---|---|
| Reihe/Serie | Molecular Biology Intelligence Unit | Molecular Biology Intelligence Unit |
| Zusatzinfo | XIII, 228 p. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Technik | |
| Schlagworte | carcinoma • Endoderm • Genetics • Tempo • Tumorigenesis |
| ISBN-10 | 0-387-33777-6 / 0387337776 |
| ISBN-13 | 978-0-387-33777-7 / 9780387337777 |
| Haben Sie eine Frage zum Produkt? |
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