Osteoimmunology (eBook)

PREFACE 6
LIST OF CONTRIBUTORS 9
CONTENTS 14
CHAPTER 1 SCHNURRI- 3: A KEY REGULATOR OF POSTNATAL SKELETAL REMODELING 16
CHAPTER 2 ECTODOMAIN SHEDDING OF RECEPTOR ACTIVATOR OF NF-.B LIGAND 29
CHAPTER 3 THE NEGATIVE ROLE OF IDS IN OSTEOCLASTOGENESIS 36
CHAPTER 4 FUNCTIONAL GENETIC AND GENOMIC ANALYSIS OF MODELED ARTHRITIS 45
CHAPTER 5 DEXAMETHSONE SUPPRESSES BONE FORMATION VIA THE OSTEOCLAST 55
CHAPTER 6 IMMUNOLOGIC REGULATION OF BONE DEVELOPMENT 59
CHAPTER 7 PTH REGULATES THE HEMATOPOIETIC STEM CELL NICHE IN BONE 69
CHAPTER 8 REGULATION OF HEMATOPOIETIC STEM CELLS IN THE OSTEOBLASTIC NICHE 73
CHAPTER 9 THE CHEMOKINE CXCL12 AND REGULATION OF HSC AND B LYMPHOCYTE DEVELOPMENT IN THE BONE MARROW NICHE 80
CHAPTER 10 OSTEOCLAST PRECURSOR CELLS 87
CHAPTER 11 INTERACTION WITH ESTROGEN RECEPTORS AS TREATMENT OF ARTHRITIS AND OSTEOPOROSIS 93
CHAPTER 12 NOVEL SIGNALING PATHWAYS AND THERAPEUTIC TARGETS IN OSTEOCLASTS 103
CHAPTER 13 THE ENIGMATIC FUNCTION OF TREM- 2 IN OSTEOCLASTOGENESIS 107
CHAPTER 14 ROLE OF CELL- MATRIX INTERACTIONS IN OSTEOCLAST DIFFERENTIATION 116
CHAPTER 15 POSITIVE AND NEGATIVE ROLES OF IL- 6, STAT3, AND SOCS3 IN INFLAMMATORY ARTHRITIS 121
CHAPTER 16 CONTROL OF OSTEOCLAST ACTIVITY AND BONE LOSS BY IKK SUBUNITS: NEW TARGETS FOR THERAPY 133
CHAPTER 17 TARGETING OSTEOPOROSIS AND RHEUMATOID ARTHRITIS BY ACTIVE VACCINATION AGAINST RANKL 143
CHAPTER 18 RANKL INHIBITION: FROM MICE TO MEN ( AND WOMEN) 151
INDEX 159