Mechanisms of Lymphocyte Activation and Immune Regulation X (eBook)

PREFACE 6
CONTENTS 8
TIR DOMAIN-CONTAINING ADAPTORS REGULATE TLR SIGNALING PATHWAYS 10
TOLL-LIKE RECEPTORS: LINKING INNATE AND ADAPTIVE IMMUNITY 19
ACTIVATION OF INSECT AND VERTEBRATE TOLL SIGNALING: FROM ENDOGENOUS CYTOKINE LIGAND TO DIRECT RECOGNITION OF PATHOGEN PATTERNS 27
GENETIC ANALYSIS OF INNATE IMMUNITY: IDENTIFICATION AND FUNCTION OF THE TIR ADAPTER PROTEINS 36
NF-KB, AN EVOLUTIONARILY CONSERVED MEDIATOR OF IMMUNE AND INFLAMMATORY RESPONSES 47
INFLUENCE OF KIR DIVERSITY ON HUMAN IMMUNITY 52
NKG2D IN INNATE AND ADAPTIVE IMMUNITY 56
SPECIFIC AND NON-SPECIFIC NATURAL KILLER CELL RESPONSES TO VIRAL INFECTION 62
ANTIGEN PROCESSING AND PRESENTATION BY DENDRITIC CELLS: CELL BIOLOGICAL MECHANISMS 67
HUMAN THYMIC STROMAL LYMPHOPOIETIN TRIGGERS DENDRITIC CELL- MEDIATED ALLERGIC INFLAMMATION AND CD4+ T CELL HOMEOSTATIC EXPANSION 72
ROLE OF TRAF6 IN THE IMMUNE SYSTEM 79
THE INNATE FUNCTIONS OF DENDRITIC CELLS IN PERIPHERAL LYMPHOID TISSUES 85
THE MANNOSE-BINDING LECTIN: AN INFECTION SUSCEPTIBILITY GENE 100
IMMUNOTHERAPY VIA DENDRITIC CELLS 105
ONTOGENY OF LAGERHANS CELLS AND GRAFT VERSUS HOST DISEASE 115
ROLE OF THE CD19 AND CD21135 RECEPTOR COMPLEX IN INNATE IMMUNITY, HOST DEFENSE AND AUTOIMMUNITY 124
ROLE OF COMPLEMENT RECEPTOR 2 IN THE PATHOGENESIS OF SYSTEMIC LUPUS ERYTHEMATOSUS 139
COMPLEMENT REGULATION DURING PREGNANCY 146
INDEX 154