Tumor Angiogenesis (eBook)

Preface 5
Contents 7
Contributors 11
Historical Overview 19
Tumor Angiogenesis: from Bench to Bedside 20
Mechanisms 46
Vasculogenesis and Angiogenesis in Development 47
Guidance of Vascular and Neuronal Network Formation 62
The Angiogenic Switch in Tumorigenesis 81
Pathophysiology and Clinical Implications of Vascular Endothelial Growth Factor 103
Regulation of Angiogenesis and Vascular Homeostasis Through the Angiopoietin / Tie System 123
Eph Receptors and Ephrins: Role in Vascular Development and Tumor Angiogenesis 135
The Role of the Neuropilins and Their Associated Plexin Receptors in Tumor Angiogenesis and Tumor Progression 149
Platelet- derived Growth Factor: Impact on Physiological and Tumor Angiogenesis 168
Hypoxia and Tumour Angiogenesis 183
Hypoxia and Angiogenesis in Glioblastomas 207
Endogenous Inhibitors of Angiogenesis 227
Thrombospondins and Angiogenesis 244
Molecular and Cellular Aspects of Heparanase 257
Vessel Maturation and Perivascular Cells 283
Adhesion Molecules in the Vascular Cell Cross- Talk 299
Homing and Differentiation of Endothelial Progenitor Cells 319
Molecular Players in Lymphangiogenesis 335
The Relationship Between Tumors and the Lymphatics: Consequences for Metastasis 351
Inflammation and Angiogenesis: Innate Immune Cells as Modulators of Tumor Vascularization 361
Arteriovenous Malformation in Mice and Men 373
Animal Models and Preclinical Anti- Angiogenic Studies 385
Vascular Endothelial Growth Factor Antibodies for Anti- Angiogenic Therapy 386
Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors for the Treatment of Cancer 403
Vascular Endothelial Growth Factor Receptor Antibodies for Anti- Angiogenic Therapy 432
Angiopoietin- 2 Antagonists for Anti- Angiogenic Therapy 460
Anti-Angiogenic Therapy with Thrombospondins 472
The Use of Orthotopic Models to Validate Antivascular Therapies for Cancer 483
Vascular Tumor Targeting 497
Molecular Imaging of Targets and Therapeutics in Tumour Angiogenesis 516
Imaging of Tumor Angiogenesis and Antiangiogenesis 534
Visualization of Microcirculation and Anti- Angiogenic Tumor Therapy 550
Cellular Actions of Angiogenesis Inhibitors on Blood Vessels 561
Antiangiogenic Therapy for Normalization of Tumor Vasculature and Microenvironment 581
Metronomic Antiangiogenic Chemotherapy: Questions and Answers 597
Anti- Angiogenic Tumor Therapy in Clinical Studies 612
The Development of Avastin 613
Clinical Development of Sorafenib ( BAY 43-9006), a VEGFR and RAF Inhibitor 656
Clinical Development of the VEGFR Signalling Inhibitor AZD2171 673
Clinical Development of Sunitinib Malate 689
The EGF( R) and VEGF( R) Pathways as Combined Targets for Anti- Angiogenesis Trials in Cancer Therapy 707
Imaging the Effect of Anti-Angiogenic Tumor Therapy in Clinical Studies 716
Vandetanib ( 739
ZACTIMA 739

Preclinical and Clinical Development 739
Integrins: Targets for Anti-Angiogenic Therapy 758
Thalidomide in Multiple Myeloma 775
Surrogate Markers of Angiogenesis 791
Vascular Disrupting Agents in Cancer Therapy 805
Subject Index 826