Transcriptional Regulation by Neuronal Activity (eBook)
XII, 425 Seiten
Springer US (Verlag)
978-0-387-73609-9 (ISBN)
Regulation of gene transcription by neuronal activity is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. In the field of activity-dependent gene expression, rapid progress is being made that can impact these, and many other areas of neuroscience.
This book offers an up-to-date picture of the field.
Regulation of gene transcription by neuronal activity is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. In the field of activity-dependent gene expression, rapid progress is being made that can impact these, and many other areas of neuroscience. The major aim of Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back is to illustrate key advances in the field - specifically how signals are transmitted to the nucleus in response to neuronal activity, what genes are activated and how this is achieved, and how these changes in gene expression alter neuronal function. About the Author:Serena M. Dudek, Ph.D. is best known for her seminal work describing Long-term synaptic Depression (LTD) in the hippocampus. Dr. Dudek heads the Synaptic and Developmental Plasticity Group at the National Institute of Environmental Health Sciences, where her laboratory studies the cellular mechanisms of synaptic plasticity in the adult and developing mammalian brain. Although once a critic of the proposed necessity of transcription for maintenance of synaptic plasticity, Dr. Dudek now devotes much of her time to work on the topic.
Preface 5
Contents 7
Activity-regulated Transcription: Getting to the Nucleus 13
Transcriptional Regulation of Activity- Dependent Genes by Birdsong 14
To the Nucleus with Proteomics 38
Transcriptional Regulation of the Tbr1- CASK- CINAP Protein Complex in Response to Neuronal Activity 62
Intracellular Calcium Waves Transmit Synaptic Information to the Nucleus in Hippocampal Pyramidal Neurons 83
Role of Action Potentials in Regulating Gene Transcription: Relevance to LTP 100
L-type Channel Regulation of Gene Expression 120
Activity-regulated Transcription: Gene Regulation 133
CREB-Dependent Transcription and Synaptic Plasticity 134
Activity-Dependent Regulation of Brain-derived neurotrophic factor Transcription 162
Role of Signal-responsive Class IIa Histone Deacetylases in Regulating Neuronal Activity- dependent Gene Expression 181
NFAT-Dependent Gene Expression in the Nervous System: A Critical Mediator of Neurotrophin- Induced Plasticity 193
Activity-Dependent Bigenomic Transcriptional Regulation of Cytochrome c Oxidase in Neurons 215
Not Just for Muscle Anymore: Activity and Calcium Regulation of MEF2- Dependent Transcription in Neuronal Survival and Differentiation 235
Activity-regulated Transcription: Role in Nervous System Function 257
Synaptic Growth and Transcriptional Regulation in Drosophila 258
MMP-9/TIMP-1 Extracellular Proteolytic System as AP- 1 Target in Response to Neuronal Activity 281
Activity-dependent Gene Transcription in Neurons: Defining the Plasticity Transcriptome 298
Transcriptional Mechanisms Underlying the Mammalian Circadian Clock 316
Intersecting Genetics with Lifestyle: the Role of Exercise and Diet in Synaptic Plasticity and Cognitive Enhancement 340
CREB Responsive Transcription and Memory Formation 379
Dynamic Transcription of the Immediate-Early Gene Arc in Hippocampal Neuronal Networks: Insights into the Molecular and Cellular Bases of Memory Formation 400
Subject Index 418
| Erscheint lt. Verlag | 24.11.2007 |
|---|---|
| Zusatzinfo | XII, 425 p. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Humanbiologie | |
| Naturwissenschaften ► Biologie ► Zoologie | |
| Technik | |
| Schlagworte | gene expression • gene regulation • gene transcription • nervous system • neurons • Neuroscience • Plasticity • synaptic plasticity |
| ISBN-10 | 0-387-73609-3 / 0387736093 |
| ISBN-13 | 978-0-387-73609-9 / 9780387736099 |
| Haben Sie eine Frage zum Produkt? |
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