Kindling 6 (eBook)

DEDICATION 6
PREFACE 7
CONTENTS 9
DEVELOPMENTAL TEMPORAL LOBE EPILEPSY IN AMYGDALA KINDLED KITTENS: An update 14
PRENATAL BETAMETHASONE EXPOSURE SUPPRESSES KINDLING EPILEPTOGENESIS IN IMMATURE RATS 24
DEVELOPMENT OF KINDLING IN IMMATURE FAST AND SLOW KINDLING RATS 31
NEONATAL HEAT- INDUCED CONVULSIONS AFFECT BEHAVIOURS IN NEONATAL, JUVENILE AND ADULT RATS 39
EXPERIMENTAL ABSENCE VERSUS AMYGDALOID KINDLING 49
PENTYLENETETRAZOL-INDUCED KINDLING AS A MODEL OF ABSENCE AND CONVULSIVE FORMS OF EPILEPSY 60
SODIUM CURRENT PROPERTIES IN DIFFERENT MODELS OF EPILEPSY 71
KINDLING THE GABAERGIC PHENOTYPE OF THE GLUTAMATERGIC GRANULE CELLS 81
HIPPOCAMPAL KINDLING AND GABAB RECEPTOR FUNCTIONS 90
ALTERED INTERACTION BETWEEN THE ENTORHINAL CORTEX AND HIPPOCAMPUS IN AMYGDALA KINDLED RATS 100
NATURE AND CONSEQUENCES OF SEIZURES ORIGINATING IN THE BRAINSTEM 107
INVOLVEMENT OF THE CLAUSTRUM AND VENTROMEDIAL THALAMUS IN EPILEPTOGENESIS 122
FROM ULTRASTRUCTURE TO NETWORKS: Kindling- induced changes in neocortex 132
KINDLING AS A TOOL FOR STUDYING THE ROLE OF SUBCORTICAL STRUCTURES IN LIMBIC SEIZURES 143
KINDLING, EPILEPSY, AND THE PLASTICITY OF NETWORK SYNCHRONIZATION 152
GENERAL DISCUSSION 1 165
ELECTROPHYSIOLOGICAL AND ANATOMICAL DIFFERENCES, BEHAVIORAL COMORBIDITIES AND GENE EXPRESSION IN FAST AND SLOW KINDLING RAT STRAINS 174
GENE EXPRESSION CHANGES IN KINDLING 183
A PROTEOMIC APPROACH TO THE MOLECULAR ANALYSIS OF KINDLING 191
AMYGDALA METABOTROPIC GLUTAMATE RECEPTORS AND KINDLING 200
INDUCTION OF Bi BRADYKININ RECEPTORS IN THE KINDLED BRAIN 210
GALANIN AND KINDLING 219
KINDLING, NEUROTROPHINS AND AXON- GUIDANCE FACTORS 228
CONDITIONAL DELETION OF TRKB PREVENTS EPILEPTOGENESIS IN THE KINDLING MODEL 240
NEUROPEPTIDE Y AND ITS RECEPTORS IN KINDLING EPILEPTOGENESIS 247
CONTRIBUTION OF PRE KINDLING AFFECTIVE STATE TO HEMISPHERIC DIFFERENCES IN THE EFFECTS ON ANXIETY OF BASOLATERAL AMYGDALA KINDLING 260
EFFECTS OF KINDLING ON SPATIAL MEMORY Characteristics and mechanisms 269
A POTENTIAL ROLE FOR THE HIPPOCAMPUS IN THE EXPRESSION OF KINDLING- INDUCED FEAR 280
DOES INADVERTENT CONDITIONING CONTRIBUTE TO THE MAJOR FEATURES OF KINDLING? 290
CONTINGENT TOLERANCE AND CROSS TOLERANCE TO ANTICONVULSANT EFFECTS IN AMYGDALA- KINDLED SEIZURES: Mechanistic and clinical implications 299
MECHANISMS OF PHARMACORESISTANCE IN THE PHENYTOIN-RESISTANT KINDLED WISTAR RAT 309
DEVELOPMENT OF NEW ANTICONVULSANTS USING THE KINDLING MODEL 318
CANNABINOIDS AND KINDLING 326
LOW FREQUENCY SINE WAVE STIMULATION DECREASES THE INCIDENCE OF KINDLED SEIZURES 336
GENERAL DISCUSSION 2 347
PREDISPOSED SUSCEPTIBILITY IN PRIMATE EPILEPTOGENESIS AND ANTI- EPILEPTOGENESIS 353
NATURAL HISTORY OF MESIAL TEMPORAL LOBE EPILEPSY WITH HIPPOCAMPAL SCLEROSIS: How does kindling compare with other commonly used animal models? 362
CLINICAL EVIDENCE OF EPILEPSY-RELATED PLASTICITY 376
PATHOLOGICAL SENSITIZATION OF THE DOPAMINE SYSTEM IN EXPERIMENTAL EPILEPTOGENESIS: Implication for the mechanism of epileptic psychosis 389
INDEX 403