Lymphangiogenesis in Cancer Metastasis (eBook)

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2009 | 2009
IX, 249 Seiten
Springer Netherland (Verlag)
978-90-481-2247-9 (ISBN)

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Lymphangiogenesis and Cancer Metastasis introduces the new field of lymphatic vessel growth and development, and its relationship to the metastatic spread of cancer cells.

The book covers all aspects of this new field from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment. Other clinical aspects explored include the mechanisms and importance of lymph node metastasis, the role of the lymphatics in lymphangioleiomyomatosis and Kaposi's sarcoma, and approaches for imaging lymphatics in cancer.

The book also covers the innovative approaches taken by researchers to explore new roles for lymphatic vessel biology in the context of cancer. The information presented in this volume, which describes the revolutionary concepts of tumor lymphangiogenesis, will be of interest to all students, scientists and oncologists who are seeking to understand the complexities of tumor metastasis.

Key Features:

  • Presents fundamental concepts of tumor lymphangiogenesis and the molecules which control this process
  • Provides a comprehensive summary of current research in this ground breaking area
  • Provides a book which links progress in basic tumor and developmental biology with current and future oncology practise
  • Is an essential text for molecular biologists, cell biologists and oncologists seeking to understand the implications of this rapidly developing area.

Lymphangiogenesis and Cancer Metastasis introduces the new field of lymphatic vessel growth and development, and its relationship to the metastatic spread of cancer cells.The book covers all aspects of this new field from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment. Other clinical aspects explored include the mechanisms and importance of lymph node metastasis, the role of the lymphatics in lymphangioleiomyomatosis and Kaposi's sarcoma, and approaches for imaging lymphatics in cancer.The book also covers the innovative approaches taken by researchers to explore new roles for lymphatic vessel biology in the context of cancer. The information presented in this volume, which describes the revolutionary concepts of tumor lymphangiogenesis, will be of interest to all students, scientists and oncologists who are seeking to understand the complexities of tumor metastasis.Key Features:Presents fundamental concepts of tumor lymphangiogenesis and the molecules which control this processProvides a comprehensive summary of current research in this ground breaking areaProvides a book which links progress in basic tumor and developmental biology with current and future oncology practiseIs an essential text for molecular biologists, cell biologists and oncologists seeking to understand the implications of this rapidly developing area.

Contents 6
Contributors 8
1 LYMPHANGIOGENESIS IN HEALTH AND DISEASE – AN OVERVIEW 11
2 INSIGHT INTO LYMPHATIC VASCULATURE DEVELOPMENT 20
3 NEW ANIMAL MODELS OF LYMPHANGIOGENESIS 35
4 MOLECULAR MECHANISMS OF LYMPH NODE METASTASIS 63
5 THE CLINICAL SIGNIFICANCE OF LYMPH- NODE METASTASIS 91
6 CLINICOPATHOLOGICAL ANALYSIS OF LYMPHATIC VESSELS AND OF LYMPHANGIOGENESIS IN HUMAN CANCER 126
7 LYMPHANGIOGENESIS AND IMAGING OF THE LYMPHATICS IN CANCER 166
8 LYMPHANGIOLEIOMYOMATOSIS 192
9 KAPOSI’S SARCOMA AND THE LYMPHATICS 217
10 LYMPHATIC PHYSIOLOGY AND FUNCTION IN HEALTHY TISSUE AND CANCER 237
Index 253

Erscheint lt. Verlag 30.9.2009
Reihe/Serie Cancer Metastasis - Biology and Treatment
Cancer Metastasis - Biology and Treatment
Zusatzinfo IX, 249 p.
Verlagsort Dordrecht
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Studium 1. Studienabschnitt (Vorklinik) Biochemie / Molekularbiologie
Naturwissenschaften Biologie Zellbiologie
Technik
Schlagworte angiogenesis • Developmental Biology • Endoplasmatisches Reticulum • Imaging • Lymphangiogenesis • Molecular mechanisms • tissue
ISBN-10 90-481-2247-3 / 9048122473
ISBN-13 978-90-481-2247-9 / 9789048122479
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