Oxidative Stress and Free Radical Damage in Neurology (eBook)

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2010 | 2011
VIII, 323 Seiten
Humana Press (Verlag)
978-1-60327-514-9 (ISBN)

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The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. With luck they may also find information on the purported role of free radicals in the pathogenesis of traumatic brain injury. Oxidative Stress and Free Radical Damage in Neurology sets the record straight, focusing on clinical and research issues regarding the interplay of free radicals and the human nervous system. Crucially, the chapters cover numerous antioxidants and their possible therapeutic role in neurological disorders. Key illnesses such as epilepsy, multiple sclerosis and Parkinson's are analyzed, and chapters also examine more general issues such as the link between free radicals and inflammation of the central nervous system. Clinicians and laboratory researchers alike will find that this book augments their understanding not only of the widespread involvement of free radicals in the central nervous system but also of some uncertainties surrounding whether free radical damage in neurology plays a primary or secondary role.
The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. With luck they may also find information on the purported role of free radicals in the pathogenesis of traumatic brain injury. Oxidative Stress and Free Radical Damage in Neurology sets the record straight, focusing on clinical and research issues regarding the interplay of free radicals and the human nervous system. Crucially, the chapters cover numerous antioxidants and their possible therapeutic role in neurological disorders. Key illnesses such as epilepsy, multiple sclerosis and Parkinson s are analyzed, and chapters also examine more general issues such as the link between free radicals and inflammation of the central nervous system. Clinicians and laboratory researchers alike will find that this book augments their understanding not only of the widespread involvement of free radicals in the central nervous system but also of some uncertainties surrounding whether free radical damage in neurology plays a primary or secondary role.

Preface 6
Contents 8
The Role of Free Radicals in the Nervous System 10
Why Is the Nervous System Vulnerable to Oxidative Stress? 27
Perinatal Hypoxic-Ischemic Neural Injury and Free Radical Injury: A Fine Balance 36
Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy 54
Oxidative Stress in Multiple Sclerosis Pathology and Therapeutic Potential of Nrf2 Activation 71
Free Radicals in Central Nervous System Inflammation 84
The Role of Reactive Oxygen Species in the Pathogenesis of Traumatic Brain Injury 104
Distinct Roles of Cyclooxygenase-1 and Cyclooxygenase- 2 in Inflammatory and Excitotoxic Brain Injury 124
Stroke and Oxidative Stress 142
Free Radicals in Epilepsy 158
Neurological Disorders Associated with Iron Misdistribution: The Therapeutic Potential of Siderophores 173
Oxidative Stress in Parkinson’s Disease 195
Tetrahydrobiopterin Deficiency 228
Radicals Attack the Ear The Toll: A Loss of Hearing 238
Reactive Oxygen Species in Mitochondrial Encephalomyopathy: Mechanisms and Effects 256
Potential Role of Oxidative Damage in Neurological Manifestations of Acute Intermittent Porphyria 296
Index 315

Erscheint lt. Verlag 19.11.2010
Reihe/Serie Oxidative Stress in Applied Basic Research and Clinical Practice
Oxidative Stress in Applied Basic Research and Clinical Practice
Zusatzinfo VIII, 323 p.
Verlagsort Totowa
Sprache englisch
Themenwelt Studium 1. Studienabschnitt (Vorklinik) Biochemie / Molekularbiologie
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Zellbiologie
Naturwissenschaften Biologie Zoologie
ISBN-10 1-60327-514-2 / 1603275142
ISBN-13 978-1-60327-514-9 / 9781603275149
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