Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology (eBook)

Alan Jackson, Professor of Neuroradiology at the University of Manchester, UK. David Buckley, Lecturer in Magnetic Resonance Imaging at the University of Manchester, UK. Previous positions at the Universities of Florida, USA and Hull, UK. Geoff Parker, Lecturer in Imaging Science at the University of Manchester, UK. Previous positions at the Institute of Neurology, London, UK and the Institute of Cancer Research, London, UK.

Foreword 6
Preface 7
Contents 9
Principles of Dynamic Contrast- Enhanced MRI 11
1 An Introduction to Dynamic Contrast-Enhanced MRI in Oncology 12
2 Contrast Agents for Magnetic Resonance Imaging 32
3 The Role of Blood Pool Contrast Media in the Study of Tumor Pathophysiology 47
4 Quantification of Dynamic Susceptibility Contrast T2* MRI in Oncology 61
5 Measuring Contrast Agent Concentration in T1- Weighted Dynamic Contrast- Enhanced MRI 76
6 Tracer Kinetic Modelling for T1- Weighted DCE- MRI 87
Imaging Techniques 99
7 Imaging Techniques for Dynamic Susceptibility Contrast- Enhanced MRI 100
8 Consensus Recommendations for Acquisition of Dynamic Contrasted- Enhanced MRI Data in Oncology 114
Clinical Applications 119
9 Dynamic Contrast-Enhanced MRI in Cerebral Tumours 120
10 Dynamic Magnetic Resonance Imaging in Breast Cancer 147
11 Dynamic Contrast-Enhanced MR Imaging for Predicting Tumor Control in Patients with Cervical Cancer 176
12 Dynamic Contrast-Enhanced MRI of Prostate Cancer 191
13 Dynamic Contrast-Enhanced MR Imaging in Musculoskeletal Tumors 214
14 Dynamic Contrast-Enhanced MRI in the Liver 237
Applications 260
15 Use of Dynamic Contrast-Enhanced MRI in Multi- Centre Trials with Particular Reference to Breast Cancer Screening in Women at Genetic Risk 261
16 Applications of Dynamic Contrast-Enhanced MRI in Oncology Drug Development 276
Subject Index 293
List of Contributors 302