Infection and Local Treatment in Orthopedic Surgery (eBook)

Preface 5
Table of Contents 6
Corresponding Authors 10
The Socio- economic Burden of Musculoskeletal Infections 14
Orthopaedic Device- related Infections 24
Epidemiology and Classification of Septic Total Hip Replacement 25
Early Radiological Diagnosis and Differential Diagnosis of Infection in Orthopaedic Surgery 33
Bacterial Strategies of Implant Colonization and Resistance 45
Pathological Findings of Septic Loosening 51
Antimicrobial Prophylaxis in Orthopaedic Surgery 61
The Limits of Systemic Antibiotics in Device- related Infections 70
Antibiotic Bone Cement as a Prophylactic Means in Joint Replacement Surgery 74
The Limits of the Local Antibiotic Therapy 79
The Role of Suppressive Surgery 85
Basic Research and Local Antibiotic Therapy 89
PMMA as Drug Delivery System and in vivo Release from Spacers 90
Antibiotic Cement Spacers in Total Hip and Total Knee Arthroplasty: Problems, Pitfalls, and Avoiding Complications 103
The Preformed Spacers: From the Idea to the Realization of an Industrial Device 123
Fatigue and Wear Characterization of the Preformed Hip Spacer 132
Fatigue Characterisation of the Preformed Knee Spacer 139
Surface Analysis of the Spacer Before and After the Clinical Use 147
Bone Loss: Does Use of the Spacer Affects it? 159
Antibiotic Impregnated Bone Grafts – What Do We Know? 165
Antibiotic- loaded Bone Allograft: Personal Experience 171
Antibiotic Loaded Cement: From Research to Clinical Evidence 181
Clinical Applications: Hip 187
The Management of Infection in THA: A Historical Perspective 188
Girdlestone Arthroplasty after Hip Prosthesis Infection – A Two- stage Revision 198
One- stage Non- cemented Revision of Septic Hip Prosthesis Using Antibiotic- loaded Bone Graft 203
Two- stage Revision of Infected Total Hip Arthroplasty. Comparison Between a Custom-made and a Preformed Spacer 210
Two- stage Revision of Infected Total Hip Replacement Using a Preformed, Antibiotic- loaded Acrylic Cement Spacer 214
Two- stage Revision of Septic Hip Prosthesis with Uncemented Implants 223
Long- stem Preformed Spacers Followed by Uncemented Implants: A Solution for Wide Femoral Opening or Bone Loss in Two- stage Revision 240
Two- stage Revision Surgery in Septic Total Hip Arthroplasty 252
One- stage, Two- stage or Multi- stage Revision: the Reason of a Choice 257
Analysis of the Gait in Patients with Hip Spacers 267
Clinical Applications: Knee 273
Septic Knee Prosthesis Revision: A Challenging Surgery 274
Management of TKA Infection – One- stage Exchange 279
Antibiotic- loaded Bone Cement Spacers for the Two- stage Revision in Total Knee Replacement 293
Key Points in Two- stage Revision for Infected Knee Arthroplasty: Bone Loss, Quality of Life Between Stages and Surgical Approach at Second Stage 301
Two- stage Revision with Preformed Knee Spacers and Modular Knee Prosthesis 309
Arthrodesis for the Treatment of Severe Knee Disease 316
Arthrodesis and Amputation in Knee Joint Infections 327
Salvage Procedures in Exposed Septic Knee Prothesis 335
Novel Applications and Perspectives 343
The Management of the Shoulder Prosthesis Infection 344
Shoulder Spacer as a Definitive Solution? 349
The Gentamicin- Vancomycin Spacer: A Pharmacological Study 357
Rationale of Nail Antibiotic Clothing and “in vivo” Animal Study 364
The Use of Antibiotic- loaded Spacers in Post- traumatic Bone Infection 372
The Use of Antibiotic- impregnated Cement in Infected Reconstructions after Resection for Bone Tumors 382
Local Antibiotic Therapy: Present and Future 390