Regulatory T Cells and Clinical Application (eBook)

Preface 5
Contents 7
Contributors 10
Immunobiology of Regulatory T Cells 18
Regulatory T Cells and the Control of Auto- Immunity: From day 3 Thymectomy to FoxP3+ Regulatory T Cells 19
FoxP3 and Regulatory T Cells 33
Thymic and Peripheral Generation of CD4+ Foxp3+ Regulatory T Cells 45
The Role of IL-2 in the Development and Peripheral Homeostasis of Naturally Occurring CD4+ CD25+ Foxp3+ Regulatory T Cells 72
IL-2 Signaling and CD4+ CD25+ Regulatory T Cells 92
TGF-Beta and Regulatory T Cells 105
TGF-ß Regulates Reciprocal Differentiation of CD4+CD25+Foxp3+ Regulatory T Cells and IL-17-Producing Th17 Cells from NaiveCD4+CD25– T Cells 124
Molecular Signalling in T Regulatory Cells 148
Regulatory T Cells in Disease and Clinical Application 166
CD4+ Foxp3+ Regulatory T Cells in Immune Tolerance 167
Regulatory T Cell Control of Autoimmune Diabetes and Their Potential Therapeutic Application 211
CD4+CD25+ Regulatory T Cells as Adoptive Cell Therapy for Autoimmune Disease and for the Treatment of Graft- Versus- Host Disease 243
Natural CD4+ CD25+ Regulatory T Cells in Regulation of Autoimmune Disease 265
Multiple Sclerosis and Regulatory T Cells 277
CD4+CD25+ Regulatory T Cells and TGF-Beta in Mucosal Inflammation 290
Induction of Adaptive CD4+CD25+Foxp3+ Regulatory T Cell Response in Autoimmune Disease 303
Regulatory T Cells in Transplantation 316
Regulatory T-cells in Therapeutic Transplantation Tolerance 333
CD4+ CD25+ Regulatory T Cell Therapy for the Induction of Clinical Transplantation Tolerance 342
Regulatory T Cells in Allergic Disease 362
Regulatory T Cells and Tumour Immunotherapy 386
Regulatory T Cells in Hepatitis and Hepatocellular Carcinoma 400
CD4+ CD25+ Regulatory T Cells in Viral Infections 413
IL-10 and TGF-ß-Producing Regulatory T Cellsin Infection 429
Human Type 1 T Regulatory Cells 460
CD8+ T Regulatory Cells in Eye Derive Tolerance 477
Immune Suppression by a Novel Populationof CD8+TCRß+ Regulatory T cells 493
Innate Regulatory iNKT Cells 505
Natural Killer T Cells Regulate the Development of Asthma 529
The Development, Activation, Function and Mechanisms of Immunosuppressive Double Negative ( DN) T Cells 546
T Cells in Immunoregulation 565
Index 571