Protein-Protein Interactions as New Drug Targets (eBook)

Organization of Scaffolds.- A-Kinase Anchoring Proteins as the Basis for cAMP Signaling.- Arrestins as Multi-Functional Signaling Adaptors.- Role of Ena/VASP Proteins in Homeostasis and Disease.- Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy.- Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox?.- Scaffolding Proteins and Cellular Signalling.- PDE4 Associates with Different Scaffolding Proteins: Modulating Interactions as Treatment for Certain Diseases.- G-Protein-Coupled Receptor-Signaling Components in Membrane Raft and Caveolae Microdomains.- Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function: Implications for Rational Drug Design.- Compartmentalised MAPK Pathways.- Dynamic Protein Complexes Regulate NF-?B Signaling.- An Oncogenic Hub: ?-Catenin as a Molecular Target for Cancer Therapeutics.- A Toolkit for Real-Time Detection of cAMP: Insights into Compartmentalized Signaling.- Cell Type-Specific Anchoring.- Scaffolding Proteins in Cardiac Myocytes.- Molecular Architecture of Signal Complexes Regulating Immune Cell Function.- Scaffolding Proteins at the Postsynaptic Density: Shank as the Architectural Framework.- Interference with Protein-Protein Interaction Sites as a New Pharmacological Concept.- Domains Mediate Protein-Protein Interactions and Nucleate Protein Assemblies.- Proline-Rich Sequence Recognition Domains (PRD): Ligands, Function and Inhibition.- Chemical Inhibition Through Conformational Stabilization of Rho GTPase Effectors.- Pharmacological Interference with Protein-Protein Interactions Mediated by Coiled-Coil Motifs.- Direct AKAP-Mediated Protein-Protein Interactions as Potential Drug Targets.