The Cell Cycle in the Central Nervous System (eBook)

Preface 6
Acknowledgmen 8
Contents 9
Contributors 12
Companion CD 16
CELL CYCLE DURING THE DEVELOPMENT OF THE MAMMALIAN CENTRAL NERVOUS SYSTEM 17
Methodological Considerations in the Evaluation of the Cell Cycle in the Central Nervous System 18
Neural Stem Cells 28
Progenitors and Precursors of Neuronsand Glial Cells 38
Vasculogenesis and Angiogenesis 45
Neuronal Migration and Malformationsof Cortical Development 56
POSTNATAL DEVELOPMENT OF NEURONS AND GLIA 69
Genome-Wide Expression Profilingof Neurogenesis in Relation to Cell Cycle Exit 70
Neurogenesis and Apoptotic Cell Death 82
Ion Channels and the Cell Cycle 91
Nonsynaptic GABAergic Communication and Postnatal Neurogenesis 105
Critical Roles of Ca 2+and K + Homeostasisin Apoptosis 115
Mammalian Neural Stem Cell Renewal 129
CONTROL OF THE CELL CYCLE AND APOPTOSIS IN GLIA 150
Methods of Determining Apoptosisin Neuro-Oncology 151
Cell Cycle, Neurological Disorders,and Reactive Gliosis 170
Potassium Channels, Cell Cycle, and Tumorigenesisin the Central Nervous System 183
ADULT NEUROGENESIS: A MECHANISM FOR BRAIN REPAIR? 198
Enhanced Neurogenesis Following Neurological Disease 199
Endothelial Injury and Cell Cycle Re- Entry 211
The Contribution of Bone Marrow-Derived Cellsto Cerebrovascular Formation and Integrity 224
Microvessel Remodeling in Cerebral Ischemia 235
Vascular and Neuronal Effects of VEGF in the Nervous System 247
Epidermal Growth Factor Receptor in the Adult Brain 267
CELL CYCLE RE-ENTRY: A MECHANISM OF BRAIN DISEASE? 280
Neurodegeneration and Loss of Cell CycleControl in Postmitotic Neurons 281
Cell Cycle Activation and the Amyloid- Protein in Alzheimer's Disease 298
Neuronal Precursor Proliferation and Epileptic Malformations of Cortical Development 308
Vascular Differentiation and the Cell Cycle 318
Adult Neurogenesis and Central Nervous System Cell Cycle Analysis 329
Neurogenesis in Alzheimer's Disease 357
THE BIOLOGY OF GLIOMAS 369
p53 and Multidrug Resistance Transportersin the Central Nervous System 370
Signaling Modules in Glial Tumorsand Implications for Molecular Therapy 386
Detection of Proliferation in Gliomas by Positron Emission Tomography Imaging 416
Transformation of Normal AstrocytesInto a Tumor Phenotype 430
Mechanisms of Gliomagenesis 445
FUTURE DIRECTIONS 459
Cell Cycle of Encapsulated Cells 460
Viral Vector Delivery to Dividing Cells 471
Electrical Stimulation and Angiogenesis 488
Developmental and Potential Therapeutic Aspectsof Mammalian Neural Stem Cells 503
Mammalian Sir2 Proteins 517
Index 533