In Vivo Models of Inflammation (eBook)

Contents 5
List of contributors 6
Preface to the first edition 8
Preface to the second edition 9
Introduction 10
Asthma 10
Mouse models 11
Guinea pig models 17
Rat models 18
Rabbit models 21
Canine models 21
Sheep models 22
Primate models 23
References 26
Introduction 38
Chronic obstructive pulmonary disease 38
In vivo modeling systems for chronic obstructive pulmonary disease 38
Elastase-induced lung inflammation and emphysema 41
Cigarette smoke-induced inflammation and lung destruction 46
Future directions 55
Conclusion 56
References 57
Introduction 67
Murine models of allergen-induced airway hyperresponsiveness and inflammation 67
Murine models of allergen-induced AHR and inflammation: functional assessments 69
Significance of murine models 76
References 85
Introduction 92
Skin inflammatory disorders 92
Atopic dermatitis models 94
Psoriasis models 105
Summary 118
References 120
Introduction 128
In vivo models of neurogenic inflammation 128
Neurogenic arterial vasodilatation and plasma extravasation 131
Mucus secretion 134
Motor effects in the airways and urinary tract 136
References 137
Introduction 143
Animal models of inflammatory bowel disease 143
Spontaneous or natural models 147
Immunological, bacterial and bacterial byproduct model 153
Animal models of physical injury 155
Genetically engineered models 161
Adoptive transfer models 167
Concluding remarks 168
References 168
Introduction 181
Preclinical models of vascular inflammation 181
Models of vascular inflammation 184
Conclusions 194
References 194
Index 204
The PIR-Series Progress in Inflammation Research 209