Sourcebook of Models for Biomedical Research (eBook)

Preface 5
Contents 6
Contributors 10
List of Color Plates 14
I INTRODUCTION 16
Animal Models for Human Diseases 17
Selection of Biomedical Animal Models 23
Improved Models for Animal Research 30
II GENERAL CONSIDERATIONS 38
The Ethical Basis for Animal Use in Research 39
Bibliographic Searching Tools on Disease Models to Locate Alternatives for Animals in Research 46
NIH Policies on Sharing of Model Organisms and Related Research Resources 53
Databases for Biomedical Animal Resources 59
Psychological Enrichment for Animals in Captivity 65
III WELL-ESTABLISHED MODELS: A Yeast, Worms, Flies, Sea Animals, and Birds 74
Integrated Network Modeling of Molecular and Genetic Interactions 75
The Sponge as a Model of Cellular Recognition 83
Sea Urchin Embryo 92
Models of Human 98
Neurodegenerative Diseases 98
Zebrafish as a Model for Development 109
Zebrafish as a Model for Studying Adult Effects of Challenges to the Embryonic Nervous System 119
Modeling Cognitive and Neurodegenerative Disorders in 127
Biomedical Research with Honey Bees 135
Establishing and Maintaining a 145
Colony for Research Laboratories 145
The Chicken as a Model Organism 167
III WELL-ESTABLISHED MODELS: B Rodents 174
Rat Knockout and Mutant Models 175
Rodent Genetics, Models, and Genotyping Methods 183
The House Mouse in Biomedical Research 191
Mouse Model for Alzheimer’s Disease 195
Guinea Pigs as Models for Human Cholesterol and Lipoprotein Metabolism 204
Reliability of Rodent Models 216
The Domestic Cat, Felis catus, as a Model of Hereditary and Infectious Disease 222
Swine in Biomedical Research 234
The Minipig as an Animal Model in Biomedical Stem Cell Research 241
The Nonhuman Primate as a Model for Biomedical Research 250
Primates as Models of Behavior in Biomedical Research 258
Primate Models for Understanding Brain Mechanisms of Cognitive Behavior 266
Animal Models for Eye Diseases and Therapeutics 277
Animal Models of Noise-Induced Hearing Loss 286
IV MODELS FOR SPECIFIC PURPOSES 299
Human and Animal Models for the Study of Muscle Pain 300
Animal Models of Parkinson’s Disease 308
Transgenic Animal Models of Neurodegenerative Diseases 318
Animal Models of Nociception and Pain 327
Nonmammalian Models for the Study of Pain 334
V MODELS OF BEHAVIOR: A Cardiovascular 346
Animal Models of Vascular Development and Endothelial Cell Biology 347
Models of Behavior 353
Animal Models for Atherosclerosis, Restenosis, and Endovascular Aneurysm Repair 361
Transgenic Mouse Models of HIV-1/AIDS and Cardiac Performance 377
V MODELS OF BEHAVIOR: B Reproduction 386
Primate Models for the Assisted Reproductive Technologies and Embryonic Stem Cell Biology 387
Rat Models of Polycystic Ovary Syndrome 395
Murine Models for Reproduction 401
Pig Model to Study Dynamics of Steroids During Ovarian Follicular Growth and Maturation 414
V MODELS OF BEHAVIOR: Drug Development and Research Models 426
Molecular Genetic Approach to Identify Inhibitors of Signal Transduction Pathways 427
Yeast as a Model System to Study DNA Damage and DNA Repair 432
V MODELS OF BEHAVIOR: D Physiology 441
Human Models of Space Physiology 442
Developmental Space Biology of Mammals 450
A Practical Approach to Animal Models of Sepsis 458
Animal Models in Functional Magnetic Resonance Imaging 468
Animal Models in Aging Research 484
V MODELS OF BEHAVIOR: E Genetics 492
Gene Targeting in Human Somatic Cells 493
Animal Models for Investigating the Causes and Mechanisms of Mammalian Germ Cell Aneuploidy 510
Genetic Models of Alzheimer’s Disease 521
V MODELS OF BEHAVIOR: F Immunology and Virology 527
Rat Models of Experimental Autoimmune Encephalomyelitis 528
Animal Models in Virology 538
Nonhuman Primate Models for AIDS 545
VI Models of other Human Diseases 553
Use of Congenic Mouse Strains for Candidate Disease Gene Identi . cation in Complex Traits 554
Animal Models of Sudden Infant Death Syndrome 561
Animal Models of Posttraumatic Stress Disorder 569
Animal Models for Studying Fetal Alcohol Syndrome, Alcohol- Related Birth Defects, and Alcohol- Related Neurodevelopmental Disorder 580
Modeling Drug and Alcohol Abuse 592
Mouse Models for Experimental Cancer Therapy 600
Rat Models of Skin Wound Healing 607
Animal Models of Prostate Cancer 615
Animal Models of Diabetes 626
Animal Models of Kidney Diseases 632
Animal Models of Multiple Sclerosis 640
Canine and Feline Models for Cancer 652
Obese Mouse Models 658
Study of Polycystic Kidney Disease in the 678
Nematode 678
Animal Models of Myelo.brosis 687
Animal Models for Bone Tissue Engineering Purposes 698
Markov Processes for Biomedical Data Analysis 711
Software Tools for Modeling Biomedical Systems 718
Developing Websites for Biomedical Research and Training 724
Building Virtual Research Communities Using Web Technology 729
Index 733