Calcium Signaling

Preface.-1 The regulation of a cell's Ca2+ signaling toolkit: the Ca2+ homeostasome.-2 Methods to detect Ca2+ in living cells.-3 Development and Optimization of FLIPR High Throughput Calcium Assays for Ion Channels and GPCRs.-4  Two-photon calcium imaging in the intact brain.-5 Signaling through the Extracellular Calcium-Sensing Receptor (CaSR).-6 Ca2+ signaling: an outlook on the characterization of Ca2+ channels and their importance in cellular functions.-7 Ryanodine receptor calcium release channels: an evolutionary perspective.-8 Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level.-9 Ryanodine Receptor Physiology and its role in Disease.-10 Phospholipase C.-11 Inositol 1,4,5-trisphosphate and its receptors.-12 Discovery and structural investigation of the IP3 receptor and the associated IRBIT, a personal account.-13 Pyridine nucleotide metabolites and calcium release from intracellular stores.-14 NAADP on target.-15 Store-operated Ca2+ entry.-16 Structure, regulation and biophysics of ICRAC, STIM/Orai1.-17 Mitochondria-associated membranes (MAMs) as hotspot Ca2+ signalling units.-18 Calcium around the Golgi apparatus: implications for intracellular membrane trafficking.-19 Calcium binding proteins.-20 Cytoplasmic calcium buffering.-21 Elementary calcium release events from the sarcoplasmic reticulum in the heart.-22 Calcium oscillations and pacemaking.-23 Calcium Oscillations and Waves in Cells.-24 Calcium signaling: From single channels to pathways.-25 Simulation strategies for calcium microdomains and calcium-regulated calcium channels.-26 Combined computational and experimental approaches to understanding the Ca2+ regulatory network in neurons.-27 α7 nicotinic ACh receptors as a ligand-gated source of Ca2+ ions: the search for a Ca2+ optimum.-28 The Biology of Protein Kinase C.-29 The role of C2 domains in PKC signaling.-30 Ca2+/calmodulin-dependent protein kinase II (CaMKII) in the heart.-31 The role of molecular regulation and targeting in regulating calcium/calmodulin stimulated protein kinases.-32 Calcium sensors in exocytosis.-33 Regulation of voltage-gated calcium channels by synaptic proteins.-34 Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels.-35 Calcium signalling in vascular smooth muscle cells: from physiology to pathology.-36 Calcium and endothelium-mediated vasodilator signaling.-37 Calcium signalling in cerebral vasoregulation.-38 Ca2+ Signaling Mechanisms in Bovine Adrenal Chromaffin cells.-39 Calcium stores in vertebrate photoreceptors.-40 Stem Cells and Calcium Signaling.-41 Calcium Signaling in Osteoclast Differentiation and Bone Resorption.-42 Calcium signaling in renal tubular cells.-43 Calcium in Epidermis.-44 Calcium Signaling in Mast Cells: Focusing on L-Type Calcium Channels.-45 Proteinase-activated receptors (PARs) and calcium signalling in cancer.-46 Mechanosensory calcium signaling.-47 Role ca2+ in mechanisms of microrheology of the red blood cell changes.-48 Calcium imaging in the zebrafish.-49 Calcium signalling in xenopus oocyte.-50 Calcium oscillations, oocyte activation, and phospholipase C zeta.-51 Nuclear calcium signaling and its involvement in transcriptional regulation in plants.-52 Remodeling of Calcium Handling in Human Heart Failure.-53 Proarrhythmic Atrial Calcium Cycling in the Diseased Heart.-54 Neuronal Calcium Signaling and Alzheimer’s Disease.-55 Voltage-gated Ca2+ channel mediated Ca2+ influx in epileptogenesis. Index.