Protein Engineering for Therapeutics, Part A

Simplified Synthetic Antibody Libraries
Generation of Dual Variable Domain Immunoglobulin Molecules for Dual-specific Targeting


Discovery of internalizing antibodies to tumor antigens from phage libraries


Optimizing properties of anti-receptor antibodies using kinetic computational models and experiments


Cell-specific siRNA delivery by peptides and antibodies


Conjugation of Anticancer Drugs Through Endogenous Monoclonal Antibody Cysteine Residues


Building and characterizing antibody-targeted lipidic nanotherapeutics


Cell-Targeting Fusion Constructs Containing Recombinant Gelonin


Stapled Peptides for Intracellular Drug Targets


Mapping of vascular zip codes by phage display


Engineering cyclic peptide toxins


Peptide Discovery using Bacterial Display and Flow Cytometry


Oral enzyme therapy for celiac sprue


Rational Design and Evaluation of Mammalian Ribonuclease Cytotoxins


Engineering Reduced-Immunogenicity Enzymes for Amino Acid Depletion Therapy in Cancer


Designed Ankyrin Repeat Proteins (DARPins): From research to therapy


Target-binding proteins based on the tenth human fibronectin type III domain (10Fn3)


Anticalins: small engineered binding proteins based on the lipocalin scaffold


T Cell Receptor Engineering


Engineering Knottins as Novel Binding Agents


Re-Engineering Biopharmaceuticals for Targeted Delivery Across the Blood-Brain Barrier


Practical Theoretic Guidance for the Design of Tumor Targeting Agents


Fusions of elastin-like polypeptides to pharmaceutical proteins


Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells