Molecular Biology of the Arterial Wall

Workshop I Lipoproteins and Lipoprotein Receptors.- LDL Receptor Mutations in Patients with Familial Hypercholesterolemia.- Lipoprotein Receptors and Their Ligands: Structure and Function of Apoproteins E and B.- The Role of HDL in Cholesterol Homeostasis of Macrophages and Reversed Cholesterol Transport.- Lipoproteins, Macrophages and Atherosclerosis.- Arterial Lipoprotein Metabolism: Site-Specific Differences Related to Susceptibility to Atherosclerotic Lesions.- Lipoprotein Disposition by the Liver: A Concerted Action of Various Cell Types.- The Macrophage and Endothelial Cell Scavenger Receptor.- Characterization of the Hepatic Scavenger Receptor.- Workshop II Growth Factors.- The Role of PDGF in Health and Disease.- Role of PDGF-like Growth Factors in Autocrine Stimulation of Cell Growth.- The PDGF Receptor as a Mediator of Mitogenesis.- Alpha-and Beta-Heparin Binding Growth Factors: Chemistry and Biology of Acidic and Basic Fibroblast Growth Factors.- Structure, Homologies and Activities of Acidic Fibroblast Growth Factor.- Endothelial Cell Growth Factor and its Receptor.- Workshop Ill Endocytosis and Exocytosis.- Intracellular Transport of Human Class I Antigens and an Adenoviral Glycoproteìn.- Molecular Mechanisms of Endocytic Sorting.- Characterisation of a Fusion Event from the Endocytic Pathway.- Membrane Boundaries Involved in the Selective Trafficking of Cell Surface Receptors.- The Molecular Basis of Human Cellular Iron Metabolism.- Workshop IV ONC Genes and Proliferative Disease.- Molecular Features Involved in Cell Surface Receptor Function and Their Role in Oncogenesis.- Transforming Activity of the fms Oncogene (CSF-1 Receptor).- Functional and Structural Analysis of the v-src and c-src Genes.- Ras Oncogenes and Cell Transformation.- Cis RegulatoryControl of mos Oncogene Expression.- Analysis of the Function of the fos Oncogene Product.- Cooperative Interactions Involving Cellular and Viral Oncogenes in the Development of Malignant Tumors.- Workshop V White Blood Cells.- The Motor of Leukocytes and Platelets: 1986.- Heterogeneity of Murine and Human Fc? Receptors.- Complement Receptors.- Cachectìn: A Macrophage Protein that Induces a Catabolic State in Infected Animals.- The Role of Cytosolic Free Calcium, (Ca2+)i, and Phosphoinositides as Intracellular Signals.- The Macrophage-Blood Interface: Cell Localisation and Recruitment in Bone Marrow, Liver and Brain.- Normal and Neoplastic Early Lymphocyte Maturation.- Molecular Regulation of Complement Gene Expression.- Workshop VI Prostaglandins and Leukotrienes.- The Role of GTP-Binding Proteins in Coupling Prostaglandin and Leukotriene Receptors to Intracellular Second Messenger Systems.- Regulation of Vascular Tone by Prostaglandins and Endothelium-Derived Relaxing Factor.- Endogenous Cysteinyl Leukotrienes as Mediators in Endotoxin Shock and Tissue Trauma.- Source and Mechanism of Release of Arachidonic Acid in Blood Platelets.- Eicosanoids and the Pulmonary Circulation.- Regulation of the Production (Leukotriene A4 Hydrolase) and the Action (Leukotriene B4 Receptor Sites) of Leukotriene B4.- Enzymic Synthesis and Degradation of Prostaglandin D2.- Receptor-Dependent Regulation of Human Polymorphonuclear Leukocyte Responses to Leukotrienes.- Leukotriene C4-Binding Proteins.- Leukotriene C Metabolizing Enzymes.- Workshop VII Biology of Smooth Muscle and Endothelium.- The Fibrinolytic System of Cultured Bovine Aortic Endothelial Cells.- Tumor Necrosis Factor/Cachectin and the Modulation of Endothelial Cell Coagulant Properties.- Membrane Glycoproteins ofEndothelial Cells and Platelets.- The Molecular Biology of Endothelial Cell von Willebrand Factor.- Induction and Regulation of Endothelial Gene Expression.- Endothelium-Vascular Smooth Muscle Interactions in Culture.- Endothelial Morphogenesis.- Closing Remarks.- Final Word.- List of Participants.- List of Sponsors.