Molecular and Cellular Therapeutics

David Whitehouse, Consultant Biotechnologist and Research Fellow, London School of Hygiene and Tropical Medicine, London. Ralph Rapley, Department of Biosciences, University of Hertfordshire, Hatfield.

List of contributors Preface

1 Cytochrome P450 pharmacogenetics: from bench to bedside

Imtiaz M. Shah, Catherine J. Breslin and Simon P. Mackay

2 Cancer biomarkers for diagnosis, prognosis and therapy

Debmalya Barh, Vaishali Agte, Dipali Dhawan, Varsha Agte and Harish Padh

3 HER2 targeted therapy-induced gastrointestinal toxicity: from the clinical experience to possible molecular mechanisms

Noor Al-Dasooqi, Rachel J. Gibson, Joanne M. Bowen and Dorothy M. Keefe

4 Antibody-targeted photodynamic therapy

Mahendra Deonarain, Ioanna Stamati and Gokhan Yahioglu

5 Anti-ageing strategy of the lung for chronic inflammatory respiratory disease – targeting protein deacetylases

Kazuhiro Ito and Nicolas Mercado

6 RNA interference: from basics to therapeutics

Sunit Kumar Singh and Praveensingh B. Hajeri

7 Delivery of RNAi effectors by tkRNAi

Hermann Lage, Andrea Kr¨uhn and Johannes H. Fruehauf

8 Human stem cell therapy

M. Ian Phillips, Yao-Liang Tang and Henrique Cheng

9 Gene therapy in organ transplantation

Thomas Ritter and Matthew D. Griffin

10 Advances in the treatment of Alzheimer’s disease

Michael S. Rafii

11 Novel molecular therapeutics in Parkinson’s disease

Susana Gonc¸alves, Hugo Vicente Miranda and Tiago F. Outeiro

12 Emerging insights and therapies for human microbial disease

Joanne L. Fothergill and Craig Winstanley

13 Vaccine design and vaccination

Niall McMullan

Index 305