Parkinson’s Disease. From Clinical Aspects to Molecular Basis

Contents: Tyrosine hydroxylase in relation to Parkinson's disease: a historical overview and future prospect.- Discovery of dopamine deficiency and the possibility of dopa therapy in Parkinsonism.- Genes of human catecholamine-synthesizing enzymes.- Receptor alterations in Parkinson's disease.- Second messengers in Parkinson's disease.- Mitochondrial energy crisis as a mechanism for nigral cell death.- Tetrahydroisoquinoline and its derivatives: the occurence and the metabolism in the brain, and the effects on catacholamine metabolism.- Can tetrahydroisoquinoline (TIQ) or N-methyl-TIQ produce parkinsonism?- Relationship between TIQs and Parkinson's disease.- Sparteine oxidation in patients with early- and late-onset of Parkinson's disease.- Association of Xba I allele (Xba I 44Kb) of the human cytochrome P-450dbI (CYP2D6) gene in Japanese patients with idiopathic Parkinson's disease.- Immunological aspects of neural transplantation.
Epidemiology of Parkinson's disease interplaying genes and environmental factors.- Topics of special interest in research of Parkinson's disease.- Importance of juvenile parkinsonism in elucidating the pathogenesis of Parkinson's disease.- Dopa-unresponsive pure akinesia or freezing.- Hereditary progressive dystonia with marked diurnal fluctation.- Positron emission tomographic study in Parkinson's disease - rigid vs tremor type.- Role of stereotaxic surgery in treatment of Parkinson's disease.- L-threo-DOPS-implications for pathophysiology of parkinsonian symptoms chronically treated with L-DOPA.- Subject Index.