Signaling Pathways and Molecular Mediators in Metastasis

Preface.-1. Introduction.I. Local invasion.-2. Reactivation of Epithelial Mesenchymal Transition in Invasive and Metastatic Cancer.-3. Biomechanical ECM Switches and Tumor Metastasis.-4. Moving aggressively: S100A4 and Tumor Invasion.- 5. Shift in TGF-b-induced signaling as culprit for local invasion and dissemination.-6. Role of Rac1-GEF and Dock180 in mediating tyrosine-kinase stimulated glioma invasion.- 7. Impact of tumor hypoxia, Src and Met signaling in the dissemination of tumor cells.II. Homing  and colonization at distant sites.-8. Cellular and Molecular Biology of Cancer Cell extravasation.- 9.  Role of CXCL12 and CXCR4 in tumor biology and metastasis.-10. Transcription factors Stat5a/b and Stat3 in prostate cancer growth and metastases.-11. Survival and growth of early metastatic foci in the bone: Role of the alpha-receptor for Platelet-Derived Growth Factor.-12. Androgen receptor in regulation of prostate cancer progression and metastasis.- 13. Integrin signaling in angiogenesis and metastatic progression in the brain.-14. Tumor and host determinants of pulmonary metastasis in bladder cancer.-15. The Influence of metastatic breast cancer on the bone microenvironment. Index.