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Research in Congenital Hypothyroidism
Kluwer Academic / Plenum Publishers (Verlag)
978-0-306-43141-8 (ISBN)
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After the Quebec meeting, we witnessed major and rapid advances in our understanding of neonatal thyroid physiology as well as screening methodology, organiza- tion, data management, the significance of an approach to false negative and false positive results,patient follow-up, and assessment of follow-up and treatment, and the psychoneurological evaluation of affected infants. Some of these aspects were further developed during a second highly pro- ductive international conference organized in Tokyo in 1982.
1. Physiopathology.- Placental transfer of substances from mother to fetus affecting fetal pituitary-thyroid function.- Transfer of thyroid hormones from the mother to the fetus.- Role of the placenta in fetal thyroid homeostasis.- Role of maternal carrier proteins in the supply of thyroid hormones to the feto-placental unit: evidence of a feto-placental requirement for thyroxine.- Maturation of thyroid hormone actions.- Regulation of intracellular thyroid hormone concentrations in the fetus.- Action of thyroid hormones on brain development.- Physiopathology - Panel discussion Moderator.- 2. Etiology.- Transient hypothyroidism in infants due to maternal TSH-receptor blocking antibodies. Character of their IgG and long-term prognosis of their infants.- Sporadic and endemic congenital hypothyroidism: evidence for autosensitization.- Thyroid growth blocking antibodies and congenital hypothyroidism.- TSH-blocking antibodies and congenital hypothyroidism.- Congenital hypothyroidism and autoimmunity. Panel discussion.- 3. Diagnosis.- Congenital defects associated with congenital hypothyroidism.- Resistance to thyroid hormones and screening for high thyroxine at birth.- Iodine nutrition and congenital hypothyroidism.- Scintigraphy in congenital hypothyroidism.- Cervical ultrasound in congenital hypothyroidism.- Neonatal echographic findings in congenital hypothyroidism.- Thyroglobulin and congenital hypothyroidism.- Significance of early diagnostic data in congenital hypothyroidism.- 4. Therapy and Neuropsychointellectual Development.- Problems in the management of patients with infantile hypothyroidism.- Treatment strategy and long term follow-up of congenital hypothyroidism.- Intellectual outcome in hypothyroid children screened at birth.- Intellectual and neuropsychological assessment of children with congenital hypothyroidism.- Mental development of patients with congenital hypothyroidism detected by screening. Quebec experience.- Neonatal thyroid screening: now we are nine.- Neurological development in congenital hypothyroidism.- 5. Abstracts of the Posters Session.- Abstracts n 1 to 38.- 6. Summary and Recommendations.- Speakers.- Discussants.- Author Index.
Reihe/Serie | NATO Science Series A ; 7 |
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Zusatzinfo | 126 black & white illustrations, biography |
Verlagsort | Dordrecht |
Sprache | englisch |
Gewicht | 860 g |
Einbandart | gebunden |
Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie |
Naturwissenschaften ► Biologie | |
ISBN-10 | 0-306-43141-6 / 0306431416 |
ISBN-13 | 978-0-306-43141-8 / 9780306431418 |
Zustand | Neuware |
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