Chronopharmaceutics – Science and Technology for ological Rhythm Guided Therapy and Prevention of D iseases

Bi-Botti C. Youan, PharmD, PhD, is Associate Professor of Pharmaceutical Sciences at the University of Missouri--Kansas City School of Pharmacy. He is on the editorial board of the Journal of Environmental Pollution; and a member of the Controlled Release Society, the American Chemical Society, and the American Association of Pharmaceutical Scientists (AAPS). Dr. Youan initiated the first AAPS Sunrise School on Chronopharmaceutical Drug Delivery in 2004. He earned his doctorate from the Universite Catholique de Louvain, Brussels, Belgium.

PREFACE. ACKNOWLEDGMENTS. CONTRIBUTORS. ABBREVATION LIST. INTRODUCTION: TIME, DIAGNOSTICS, AND THERAPEUTICS-BEYOND CIRCADIAN MARKER RHYTHM-GUIDED TREATMENT ( Franz Halberg, Germaine Corne lissen, and Othild Schwartzkopff ). 1 OVERVIEW OF CHRONOPHARMACEUTICS ( Bi-Botti C. Youan ). 2 CHRONOGENETICS ( Franck Delaunay ). 3 CHRONOPHARMACOKINETICS ( Bernard Bruguerolle ). 4 CHEMICAL OSCILLATOR SYSTEMS FOR CHRONOTHERAPY ( Steven A. Giannos ). 5 DIFFUCAPS TECHNOLOGY FOR CONTROLLED RELEASE DRUG DELIVERY ( Gopi Venkatesh ). 6 CHRONOTOPICt TECHNOLOGY (M . E. Sangalli, A. Maroni, L. Zema, M. Cerea, and A. Gazzaniga ). 7 CHRONOTHERAPY USING EGALET TECHNOLOGY ( Daniel Bar-Shalom, Clive G. Wilson, and Neena Washington ). 8 CHRONSETt: AN OROS DELIVERY SYSTEM FOR CHRONOTHERAPY ( Liang C. Dong, Crystal Pollock-Dove, and Patrick S.L. Wong ). 9 CONTROLLED RELEASE MICROCHIPS ( Karen Daniel, Hong Linh Ho Duc, Michael Cima, and Robert Langer ). 10 IMPLICATIONS AND APPLICATIONS OF CIRCADIAN SUSCEPTIBILITY RHYTHMS: CHRONOMICS AND ANESTHESIA ( Franz Halberg, Germaine Corne' lissen, and Othild Schwartzkopf f). 11 TREATMENT WITH OPEN EYES: MARKERS-GUIDED CHRONOTHERANOSTICS ( Germaine Corne lissen, and Franz Halberg ). INDEX.