Nucleosides and Nucleotides as Antitumor and Antiviral Agents

Buch | Hardcover

336 Seiten

1993
Kluwer Academic/Plenum Publishers (Verlag)
978-0-306-44520-0 (ISBN)

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Due to the worldwide epidemic of acquired immunodeficiency syndrome (AIDS), the past ten years have witnessed a flurry of activity in the chemotherapy of viral diseases. Unprecedented scientific efforts have been made by scientists and clinicians to combat infections of human immunodeficiency virus (HIY), the causative agent. Looking back over the past ten years, we have made remarkable progress toward the treatment of the viral disease: isolation of HIV only two years after the identification of the disease, plus major strides in the areas of the molecular biology and virology of the retrovirus, etc. More remarkably, the discovery of the chemotherapeutic agent AZT (Retrovir) was made within two years after the isolation and identification of the virus, followed by unprecedented drug development efforts to culminate in the FDA approval of AZT in twenty-three months, which was a record-breaking time for approval of any drug for a major disease. The last six to seven years have particularly been an exciting and productive period for nucleoside chemists. Since the activity of AZI' was established in 1985, nucleoside chemists have had golden opportunities to discover additional anti-HIV nucleosipes, which are hoped to be less toxic and more effective than AZT, and the opportunity continues. As we all are aware, AZT possesses extremely potent anti-HIY activity, and no other nucleoside or non nucleoside has surpassed the potency of AZT in vitro.

Design of New Types of Antitumor Nucleosides: The Synthesis and Antitumor Activity of 2?-Deoxy-(2?-C-Substituted)Cytidines.- Lithiation Chemistry of Uridine Derivatives: Access to a New Anti-HIV-1 Lead.- A Synthesis of 2?-Fluoro- and 3?-Fluoro-Substituted Purine Nucleosides via A Direct Approach.- Allenols Derived from Nucleic Acid Bases — A New Class of Anti-HIV Agents: Chemistry and Biological Activity.- Structure-Activity Relationship among HIV Inhibitory 4?-Substituted Nucleosides.- Adenosine-Derived 5?-?-Halo Thioether, Sulfoxide, Sulfone, and (5?-Halo)Methylene Analoguestlnhibition of S-Adenosyl-L-Homocysteine Hydrolase.- Approaches to Novel Isomeric Nucleosides as Antiviral Agents.- Carbocyclic 7-Deazaguanosine Nucleosides as Antiviral Agents.- L-Ascorbic and D-Isoascorbic Acids: Chiron Sources for 1?,2?-SECO-Nucleosides/tides, Phosphonates, and Other Molecules of Biological Interest.- Synthesis and Anticancer and Antiviral Activity of Certain Pyrimidine Nucleoside Analogues.- Structure-Activity Correlations of 2?,3?-Dideoxy- and 2?,3?-Didehydro-2?,3?-Dideoxypyrimidine Nucleosides as Potential Anti-HIV Drugs.- Stereocontrolled Routes for the Synthesis of Anti-HIV and Anti-HBV Nucleosides.- 5-Substituted Arabinofuranosyluracil Nucleosides as Antiherpesvirus Agents: From araT to BV-araU.- Conformational Studies and Anti-HIV Activity of Mono- and Difluorodideoxy Nucleosides.- Crystal Structures and Molecular Conformations of Anti-HIV Nucleosides.- Modified Oligoribonucleotides: Synthesis and Preliminary Evaluation of ?-RNA.- Towards Second-Generation Synthetic Backbones for Antisense Oligonucleosides.

Zusatzinfo	18 Illustrations, black and white; X, 336 p. 18 illus.
Verlagsort	New York
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie ► PTA / PKA
	Naturwissenschaften ► Chemie ► Analytische Chemie
ISBN-10	0-306-44520-4 / 0306445204
ISBN-13	978-0-306-44520-0 / 9780306445200
Zustand	Neuware