Neurosteroids -

Neurosteroids

A New Regulatory Function in the Nervous System

Etienne-Emile Baulieu (Herausgeber)

Buch | Hardcover
378 Seiten
1999
Humana Press Inc. (Verlag)
978-0-89603-545-4 (ISBN)
213,99 inkl. MwSt
Unveils new physiological properties of neurosteroids, the related steroids that can form and metabolize the brain, as well as throughout the entire nervous system. The discussions here may be the key to discovering new approaches to the repair of the nervous system after trauma and degenerative diseases. In the CONTEMPORARY ENDOCRINOLOGY series.
Etienne-Emile Baulieu, the discoverer of neurosteroids, and a panel of distinguished scientists and clinical researchers exhaustively and critically review all facets of neurosteroids involved in behavior, stress, memory, depression, anxiety, aging of the brain, and neurodegenerative diseases. These contributors illuminate the role of neurosteroids in brain development and plasticity and detail their neuromodulatory influence on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. Clearly pointing the way toward novel pharmaceutical agents that may be of significant therapeutic value, particularly with regard to aging mental functions, Neurosteroids: A New Regulatory Function in the Nervous System offers neurobiologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians the first comprehensive, state-of-the-art review of these important bioactive molecules.

1 Neurosteroids: From Definition and Biochemistry to Physiopathologic Function.- 2 Molecular Biology and Developmental Regulation of the Enzymes Involved in the Biosynthesis and Metabolism of Neurosteroids.- 3 Cytochrome P450 in the Central Nervous System.- 4 Steroidogenic Factor 1 Plays Key Roles in Adrenal and Gonadal Development and in Endocrine Function.- 5 Peripheral-Type Benzodiazepine Receptor: Role in the Regulation of Steroid and Neurosteroid Biosynthesis.- 6 Aspects of Hormonal Steroid Metabolism in the Nervous System.- 7 The Selective Interaction of Neurosteroids with the GABAA Receptor.- 8 Potentiation of GABAergic Neurotransmission by Steroids.- 9 Neurosteroid Antagonists of the GABAA Receptors.- 10 Modulation of Ionotropic Glutamate Receptors by Neuroactive Steroids.- 11 Steroidal Modulation of Sigma Receptor Function.- 12 Steroid Modulation of the Nicotinic Acetylcholine Receptor.- 13 Neuroactive Steroid Modulation of Neuronal Voltage-Gated Calcium Channels.- 14 Gonadal Hormone Regulation of Synaptic Plasticity in the Brain: What Is the Mechanism?.- 15 Steroid Effects on Brain Plasticity: Role of Glial Cells and Trophic Factors.- 16 Steroid Receptors in Brain Cell Membranes.- 17 Novel Mechanisms of Estrogen Action in the Developing Brain: Role of Steroid/Neurotrophin Interactions.- 18 Neurosteroids: Behavioral Studies.- 19 Remarkable Memory-Enhancing Effects of Pregnenolone Sulfate with Pheromone-Like Sensitivity: An Amplificatory Hypothesis.- 20 The Neuropsychopharmacological Potential of Neurosteroids.

Erscheint lt. Verlag 23.7.1999
Reihe/Serie Contemporary Endocrinology ; 16
Zusatzinfo XVI, 378 p.
Verlagsort Totowa, NJ
Sprache englisch
Maße 178 x 254 mm
Themenwelt Medizinische Fachgebiete Innere Medizin Endokrinologie
Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Studium 1. Studienabschnitt (Vorklinik) Physiologie
Naturwissenschaften Biologie Humanbiologie
ISBN-10 0-89603-545-X / 089603545X
ISBN-13 978-0-89603-545-4 / 9780896035454
Zustand Neuware
Haben Sie eine Frage zum Produkt?
Mehr entdecken
aus dem Bereich

von Clemens Marischler

Buch | Softcover (2024)
Urban & Fischer in Elsevier (Verlag)
29,00