Multiple Drug Resistance in Cancer 2

P-glycoprotein structure and evolutionary homologies.- Molecular analysis of the multidrug transporter, P-glycoprotein.- Mutagenesis of the putative nucleotide-binding domains of the multidrug resistance associated protein (MRP). Analysis of the effect of these mutations on MRP mediated drug resistance and transport.- Membrane topology of the human multidrug resistance-associated protein (MRP) and its homologs.- A new aspect on glutathione-associated biological function of MRP/GS-X pump and its gene expression.- Intracellular distribution of anthracyclines in drug resistant cells.- Use of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistance.- Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP.- Topoisomerase I inhibitors and drug resistance.- Mechanisms of resistance to alkylating agents.- Drug resistance and DNA repair in leukaemia.- Nucleotide excision repair and anti-cancer chemotherapy.- Protein kinases and multidrug resistance.- New insights into the kinetic resistance to anticancer agents.- The extended-MDR phenotype.- Role of oxygenation and vascularization in drug resistance.- Transcriptional regulation of MDR genes.- Cytokine-mediated reversal of multidrug rsistance.- The role of oncogene in drug resistance.- Apoptosis resistance in tumor cells.- Regulation of caspase activation in apoptosis: implications for transformation and drug resistance.- Regulation of keratin and integrin gene expression in cancer and drug resistance.