Nucleic Acid Switches and Sensors -

Nucleic Acid Switches and Sensors

Scott K. Silverman (Herausgeber)

Buch | Softcover
125 Seiten
2011
Springer-Verlag New York Inc.
978-1-4419-4248-7 (ISBN)
160,49 inkl. MwSt
describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors.
In this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed.

Artificial Nucleic Acid Switches and Sensors.- Allosteric Ribozymes as Molecular Switches and Sensors.- Ribozymes and Deoxyribozymes Switched by Oligonucleotides.- Ribozymes Switched by Proteins.- Fluorescence-Signaling Nucleic Acid-Based Sensors.- Natural Nucleic Acid Switches and Sensors.- Protein-Induced RNA Switches in Nature.- Riboswitches as Genetic Control Elements.- Switchable RNA Motifs as Drug Targets.

Zusatzinfo 3 Illustrations, color; 54 Illustrations, black and white; IX, 125 p. 57 illus., 3 illus. in color.
Verlagsort New York, NY
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Mikrobiologie / Infektologie / Reisemedizin
Studium 2. Studienabschnitt (Klinik) Humangenetik
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Genetik / Molekularbiologie
ISBN-10 1-4419-4248-3 / 1441942483
ISBN-13 978-1-4419-4248-7 / 9781441942487
Zustand Neuware
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