Foreign DNA in Mammalian Systems
Wiley-VCH Verlag GmbH (Hersteller)
978-3-527-61346-5 (ISBN)
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It is unlikely that the established genomes of present day organisms remain stable forever. It is conceivable that foreign DNA can gain entry into individual cells of an organism. Foreign DNA is defined as genetic material that derives from another organism of the same or a different species. The natural environment is heavily 'contaminated' with such foreign DNA, and mammals, like other organisms, are frequently exposed to foreign DNA in their environment, notably by ingesting their daily food supply. By necessity, the gastrointestinal tract also of all mammalian organisms is constantly in contact with foreign DNA. So far, next to nothing is known about defense mechanisms in mammals against the intrusion of foreign DNA. At least in cells growing in culture, the uptake and genomic fixation by integration of foreign DNA can readily be demonstrated.For a number of reasons, the author has considered it important to investigate the phenomena and mechanisms involved in the interaction of foreign DNA with mammalian cells and organisms in detail.
Walter Doerfler studied medicine in Munich, Erlangen and Hamburg. After that, he was intern at Mercer Hospital Trenton, NJ, USA. He held postdoctoral degrees from 1961 to 1963 at the Max Planck Institute of Biochemistry in Munich and from 1963 to 1966 at the Department of Biochemistry, Stanford University Medical School.
Introduction MOLECULAR BIOLOGY Uptake of Foreign DNA Modes of Persistence of Foreign DNA Integrative Recombination Expression of Integrated Foreign DNA De novo Methylation of Foreign DNA Alterations of Cellular DNA Methylation Patterns Consequences for Cellular Gene Expression Patterns Insertional Mutagenesis Experiments in Cell Culture and with Animals Uptake of Foreign DNA via the Gastrointestinal Tract RELEVANCE FOR DIFFERENT BIOLOGICAL PROBLEMS Oncogenic Viruses Tumor Biology Reverse Genetics Transgenic Organisms Mutagenesis Human Somatic Gene Therapy Injection of DNA into Animals and DNA Vaccines Uptake of Foreign DNA via the Gastrointestinal Tract and Human Nutrition Thoughts on Evolution Gene Technology and Biosafety FUTURE RESEARCH GENERAL IMPACT References
| Verlagsort | Weinheim |
|---|---|
| Sprache | englisch |
| Maße | 174 x 245 mm |
| Gewicht | 510 g |
| Themenwelt | Naturwissenschaften ► Biologie |
| ISBN-10 | 3-527-61346-3 / 3527613463 |
| ISBN-13 | 978-3-527-61346-5 / 9783527613465 |
| Zustand | Neuware |
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