Polymorphism – In the Pharmaceutical Industry

After gaining his PhD in physical chemistry from Basel University, Switzerland, Rolf Hilfiker did his postdoc at Stony Brook, USA. He returned to Basel as a research fellow, initially at the university and then at Ciba-Geigy. In 1997 he became head of Stability & Kinetics group at Novartis, joining Solvias two years later where he is currently head of the department Solid-State Development. Dr. Hilfiker has taught physical chemistry in New York and Basel, and is a recipient of the Jacottet-K?ard and a Treubel Fellowship. He is author of more than 50 scientific publications in various areas of physical chemistry.

Relevance of Solid-state Properties for Pharmaceutical Products Thermodynamics of Polymorphs Characterization of Polymorphic Systems using Thermal Analysis Solid-state NMR Spectroscopy Vibrational Spectroscopic Methods in Pharmaceutical Solid-state Characterization Crystallography for Polymorphs Light Microscopy The Importance Solvates Physical Characterization of Hygroscopicity in Pharmaceutical Solids The Amorphous State Approaches to Polymorphism Screening Salt Selection Processing-induced Phase Transformations and their Implications on Pharmaceutical Product Quality Polymorphism and Patents from A Chemist's Point of View Scientific Considerations of Pharmaceutical Solid Polymorphism in Regulatory Applications