NMR–Spectroscopy – Data Acquisition Second Edition

Christian Schorn is Principal Investigator for GlaxoSmithKline Research & Development Limited, Tonbridge, UK. He studied Chemistry at the Universitat zu Koln, Germany, and made his diploma thesis in Chemical Engineering in the central research department of the Bayer AG, Leverkusen. His PhD thesis at the Universitat zu Koln included preparative work and structural investigation using 19F NMR spectroscopy. For a post doctoral stay he went to the Universitat Bern, Switzerland, where he worked on pulse program development and structural characterization in the NMR service lab of Peter Bigler. During his stay he started the first edition of the present compendium. The work was finished during his post doctoral fellowship at the ETH Zurich, Switzerland, where he worked with Nobel Prize winner Kurt Wuthrich on mammalian prion protein structures. Brian Taylor is at the University of Sheffield where he holds the position of NMR Service manager. He was born in London and obtained both his degrees at the University of Bristol, his doctorate under the supervision of Robin Goodfellow. He was a post doctoral fellow at University of Bristol, where he worked with Gordon Stone. He moved to the University of Sheffield in 1974 to take charge of the Department of Chemistry s first FT NMR spectrometer. He is interested in the application of NMR spectroscopy in undergraduate teaching and has been instrumental in pioneering the use of NMR automation in British Universities.

Preface to 2nd Edition. Acknowledgements. 1. Introduction. 1.1 Scope and Audience. 1.2 Software. 1.3 The Check its. 1.4 Book Layout. 1.5 References. 2. Background on Simulation. 2.1 Description of real Samples Spin Systems and Processes on Spin Systems. 2.2 Description of Pulse Sequences. 2.3 Signal Detection. 2.4 References. 3. Acquisition and Processing. 3.1 Excitation of nuclear spins and their response detection. 3.2 One dimensional Experiments. 3.3 Two dimensional Experiments. 3.4 NMR SIM options. 3.5 References. 4. Experiment Setup in NMR SIM. 4.1 Spin Systems and Pulse Programs. 4.2 Experiment and Processing Parameters. 4.3 Using the Bloch Simulator. 4.4 References. 5. Complete Sequences, Elements and Building Blocks. 5.1 The Philosophy of Pulse Sequences. 5.2 Single Pulse and Simple Multi Pulse Experiments. 5.3. Building Blocks and Elements Part One. 5.4 Homonuclear Correlation Experiments. 5.5 Building Blocks and Elements Part Two. 5.6 Heteronuclear Correlation Experiments I: nX Detected Experiments. 5.7 Heteronuclear Correlation Experiments II: 1H Detected Experiments. 5.8 Building Blocks and Elements Part Three. 5.9 Latest Developments in NMR. 5.10 References. Glossary. Index.