Multicomponent Reactions

Jieping Zhu received his BSc from Hanzhou Normal University in 1984 and his MSc from Lanzhou University in 1987 under Professor Y. L. Li. In 1991, he obtained his PhD from the Universite Paris XI under Professor H. P. Husson. After 18 months post doctoral research with Professor Sir D. H. R. Barton at Texas A & M University in USA, he joined the Institut de Chimie des Substances Naturelles (CNRS) in December 1992, where he is currently Director of Research. His main research interests center on the development of novel synthetic methods, their application in the synthesis of bioactive natural products, and the design of novel multicomponent reactions. Dr. Zhu has published over 110 research papers. Hugues Bienayme gained his PhD in organic chemistry at the university of Paris under Professor A. Lubineau, than took up a post doctoral position at the University of Geneva under the supervision of Professor W. Oppolzer. He joined Rhone Poulenc (Aventis) in 1991 where he held various research positions in process and discovery chemistry. From 1995 to 2000 he was head of the combinatorial and discovery chemistry group for the company s central research department, developing multi component condensations as a general tool to accelerate drug discovery. In 1996 the company awarded him the title "associate professor". In 2001, Dr. Bienayme founded Chrysalon, a start up in the field of combinatorial chemistry. After the company s merger in 2003, he became managing director and CSO of Urogene, a biotech company dedicated to discovering new drugs in urology. Hugues Bienayme is the author or co author of more than 40 publications and patents.

Multicomponent Reactions with Organoboron Compounds Free Radical Mediated Multicomponent Coupling Reactions Applications of Multicomponent Reactions in Drug Discovery Lead Generation to Process Development The Discovery of New Isocyanide Based Multicomponent Reactions Metal catalyzed Multicomponent Reactions Multicomponent Reactions in the Total Synthesis of Natural Products Asymmetric Isocyanide Based Multicomponent Reactions The Biginelli reaction Asymmetric Isocyanide Based Multicomponent Reactions The Domino Knoevenagel Hetero Diels Alder Reaction and Related Transformations Catalytic Asymmetric Multicomponent Reactions Algorithm Based Methods for the Discoverey of Novel Multicomponent Reactions Post condensation Modifications of the Passerini and Ugi Reactions