Neurotransmitters and Neuromodulators
Wiley-VCH Verlag GmbH (Hersteller)
978-3-527-60073-1 (ISBN)
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What are the biological effects of neuropeptides and other neuroactive substances? What are their receptors, their pharmaceutical applications? The intensive search for answers to these questions culminated in the 2000 Nobel Prize for Medicine/Physiology being awarded to A. Carlsson, P. Greengard, and E. Kandel for their pioneering research in signal transduction in the nervous system. This handbook gives a short but detailed overview of neuroactive substances, covering all neurotransmitters and most neuromodulators. It provides clear and comprehensive information on their biosynthesis and degradation, localization, receptors, signal transduction pathways, and biological effects in the central nervous system. Introductory chapters on general aspects and on methods for analyzing neuroactive substances make this a valuable tool for researchers, teachers, and advanced students in molecular biology, biochemistry, medicine, neurosciences, pharmacology, and physiology.
INTRODUCTION Neuroactive Substances Receptors and Transporters Distribution and Localization of Neurotransmitters and Neuromodulators The Blood-Brain Barrier Volume Transmission and Wiring Transmission METHODS FOR STUDYING NEUROACTIVE SUBSTANCES Bio- and Radioisotope Assays Microdialysis and Electrochemical Detection Chromatography Autoradiography Immunohistochemical Methods In-situ Hybridization Staining and Neuroanatomical Tract Tracing Electrophysiology Behavioral Testing NEUROTRANSMITTERS Acetylcholine Dopamine GABA (Gamma-Amino Butyric Acid) Glutamate and Aspartate Glycine Histamine Norepinephrine Serotonin (5-hydroxytryptamine) NEUROMODULATORS Adrenocorticotropic Hormone (ACTH) Anandamide Angiotensin Atrial Natriuretic Factor Calcitonin and Calcitonin Gene-Related Protein Cholecystokinin Corticotropin-Releasing Factor (CRF) Dynorphin Eicosanoids and Arachidonic Acid Endorphin Enkephalin Galanin Growth Hormone-Releasing Hormone Gonadotropin-Releasing Hormone Interleukin Melanin-Concentrating Hormone Melanocyte-Stimulating Hormone Neurotensin Nitric Oxide Nociceptin (Orphanin FQ) Neuropeptide Y PACAP (pituitary adenylate cyclase-activating polypeptide) Proopiomelanocortin Purines Somatostatin Substance P and Tachykinins Thyrotropin-Releasing Hormone Tyr-MIF-1 Family Vasoactive Intestinal Polypeptide (VIP) Vasopressin and Oxytocin
| Erscheint lt. Verlag | 22.5.2003 |
|---|---|
| Verlagsort | Weinheim |
| Sprache | englisch |
| Maße | 150 x 250 mm |
| Gewicht | 1 g |
| Themenwelt | Naturwissenschaften ► Biologie |
| Naturwissenschaften ► Chemie | |
| ISBN-10 | 3-527-60073-6 / 3527600736 |
| ISBN-13 | 978-3-527-60073-1 / 9783527600731 |
| Zustand | Neuware |
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