Ligand Design for G Protein–coupled Receptors

Didier Rognan leads the Drug Bioinformatics Group at the Laboratory for Molecular Pharmacochemistry in Illkirch (France). He obtained a graduate degree in Pharmacy from the University of Rennes and completed his PhD in Medicinal Chemistry at the University of Strasbourg under the supervision of Camille G. Wermuth in 1989. Moving to the Swiss Federal Institute of Technology in Z?he became Assistant Professor at the ETH before being named a research director at the CRNS in Illkirch near Strasbourg in 2000. Professor Rognan is mainly interested in all aspects (method development, applications) of protein-based drug design and virtual screening.

Preface.1. G Protein-coupled Receptors in the Human Genome (R. Fredriksson & H. Schioth).2. Why G Protein-coupled Receptors Databases are Needed (J. Haiech, et al.).3. A Novel Drug Screening Assay for G Protein-coupled Receptors (B. O'Dowd, et al.).4. Importance of GPCR Dimerization for Function: The Case of the Class C GPCRs (L. Prezeau, et al.).5. Molecular Mechanisms of GPCR Activation (R. Bywater & P. Denny-Gouldson).6. Allosteric Properties and Regulation of G Protein-coupled Receptors (J. Galzi, et al.).7. Chemogenomics Approaches to Ligand Design (T. Klabunde).8. Strategies for the Design of pGPCR-targeted Libraries (N. Savchuk, et al.).9. Ligand-based Rational Design: Virtual Screening (D. Clark & C. Higgs).10. 3-D Structure of G Protein-coupled Receptors (L. Pardo, et al.).11. 7TM Models in Structure-based Drug Design (F. Blaney, et al.).12. Receptor-based Rational Design: Virtual Screening (D. Rognan).Subject Index.