Alzheimer: 100 Years and Beyond

Alois Alzheimer.- Concerning a unique disease of the cerebral cortex.- The history of Alois Alzheimer's first case Auguste D..- Alois Alzheimer and the beginnings of research into Alzheimer's disease.- Alois Alzheimer and the myth of the pioneer.- The beginning of modern research.- Alzheimer's Disease at mid-Century (1927-1977) and a little more.- A chapter in the development on Alzheimer's disease research.- Anatomy & Neuropsychology.- Anatomical changes underlying dementia in Alzheimer's disease.- Staging of cortical neurofibrillary inclusions of the Alzheimer's type.- Of stains and brains: a brief account of how microscopic and clinical observations contributed to the understanding of Alzheimer's disease.- Presenile forms of Alzheimer's disease in 2006.- Cholinergic Deficit.- The cholinergic deficit in Alzheimer's disease.- Acetylcholine in AD: Expectations meet reality.- Amyloid and Genetics.- The Discovery of ? Amyloid.- Pathways to the discovery of the neuronal origin and proteolytic biogenesis of A? amyloid of Alzheimer's disease.- The Amyloid Hypothesis: history and alternatives.- Segregation of a missense mutation in the amyloid ?-protein precursor gene with familial Alzheimer's disease.- From the amyloid ? protein (A4) to isolation of the first Alzheimer's disease gene: amyloid ? (A4) precursor protein (APP).- Commentary on "Correlative memory deficits, A? elevation, and amyloid plaques in transgenic mice".- Vision for the future.- PS1, PS2, and APP mutations that cause Alzheimer's disease increase A?42.- Amyloid precursor protein, Alzheimer's disease, and Down's syndrome.- Catabolism of amyloid ? peptide and pathogenesis of sporadic Alzheimer's disease: towards understanding the underlying mechanisms.-Synaptic activity, amyloid-? and Alzheimer's disease.- Molecular pathogenesis of Alzheimer's disease in human peripheral cells: platelets show it all!.- The neuronal origin hypothesis of cerebral amyloid angiopathy.- A neuropathologist and Alzheimer genetics.- Genetics, molecular biology, and animal modeling of Alzheimer's disease.- The genetic Alzheimer-frontotemporal dementia spectrum.- Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. The role of amyloid in dementia and stroke.- Physiological generation of Amyloid ?-peptide and its Consequences for Alzheimer's disease research.- Activation of ?-secretase as an approach for treatment of Alzheimer's disease.- Challenges to the enigma of ?-secretase and to Alzheimer's disease.- Targeting ?-Secretase for Alzheimer's Disease.- The Presenilin/gamma-secretase complex and its potential as a drug target in Alzheimer's Disease.- Identification of ?-secretase.- ApoE.- Apolipoprotein E and Alzheimer's disease: A brief retrospective.- Apolipoprotein E4: From synaptic remodeling to genetic risk factor in both familial and sporadic Alzheimer's disease.- Tau.- The Alzheimer tangle - 100 years on..- Immunological demonstration of tau protein in neurofibrillary tangles.- Bulk isolation of neurofibrillary tangles and discoveries of tau and its abnormal hyperphosphorylation.- The natural and molecular history of Alzheimer's disease: Tau is part of the story.- Tau focused drug discovery for Alzheimer's disease and related Neurodegenerative Tauopathies.- Ubiquitin is a component of paired helical filaments in Alzheimer's disease.- Influence of tau on neuronal traffic mechanisms.- The Search for structure of tau and paired helical filaments.- OxidativeStress.- The Changing landscape of Alzheimer's disease: From Insoluble to Soluble and from Pathogen to Protector.- Molecular and cellular pathways towards and away from Alzheimer's disease.- Epidemiology.- Paquid: an integrated, multidisciplinary, population-based approach to normal and pathological cerebral aging.- Imaging.- Hippocampal imaging in the early diagnosis of AD, 1988 to 2006.- Detecting Early-Stage Alzheimer's Disease in MCI and PreMCI: The value of informants.- Imaging the pathology of Alzheimer's disease: Building on a century-Old blueprint.- Therapeutical Perspectives.- How do we test drugs?.- Inflammation and the lesions of Alzheimer's disease.- A? immunotherapy prevents and Reverses Alzheimer's disease neuropathology.- Immunotherapy of Alzheimer's disease.- "Magic" bullets, shotguns or cocktails to treat or prevent Alzheimer's disease?.- The seventh age of man: Solving senility.- Forum and Network.- Fondation Ipsen and Alzheimer's disease: a 20-year relationship.- Alzheimer Research Forum: A Knowledge Base and e-Community for AD Research.