Organic Syntheses Based on Name Reactions

Alfred Hassner was born in 1930. He survived the holocaust as a young child. After WW II, he enrolled to the Technische Hochschule in Vienna (1949-1951), and then received his BSc from the University of Nebraska (1952). He obtained his PhD under Norman Cromwell at the University of Nebraska (1956) and then was a postdoc with Louis Fieser at Harvard University. He joined the University of Colorado at Boulder (1957) and became a Full Professor at the age of 36 (1966). In 1975, he moved to SUNY at Binghamton and in 1983 he joined Bar-Ilan University in Israel, where he was professor and after retirement Professor Emeritus, until his sad demise recently (2024) at the age of 94. Hassner mentored over 50 graduate students and more than 60 postdocs, published more than 320 research articles and 14 books and monographs, and has had a major impact on chemical science for the last 7 decades. Some of his most known contributions include the stereoselective introduction of nitrogen functionalities into organic molecules, the synthesis of steroidal heterocycles and other biologically active targets. He was one of the first to recognize the application of NMR half-widths to stereochemical structure assignments before high resolution NMR became available. Many useful reagents and concepts in organic synthesis are registered to his name. For example, he first proposed the concept of regiochemistry and regioselectivity, now universally used terminologies in organic chemistry. As a world-renowned expert in organic synthesis, he has held visiting professorships and appointments in many universities worldwide and also served as a valuable consultant for many industrial companies around the world. Hassner served as the president of the Israel Chemical Society - ICS (1991-1994). In 2007, he received the ICS prize for Excellence. In 2016, he received Honorary membership award for his lifetime achievement and outstanding contributions. Irishi N N Namboothiri was born in the southern Indian state Kerala in 1964. He received his MSc from Mangalore University (1988) and PhD from Indian Institute of Science, Bangalore (1994). He carried out postdoctoral research at Bar-Ilan University, Israel (1995-96), University of North Texas (1997-98) and Columbia University, USA (1999). After a brief stint as Senior Research Scientist at Sabinsa Corporation, New Jersey (2000), he joined the Department of Chemistry, Indian Institute of Technology (IIT) Bombay, Mumbai (2001) where he is currently a senior professor. His research interests include organic synthesis, development of new synthetic methodologies, asymmetric catalysis, mechanistic studies and materials chemistry. He is elected fellow of the Indian Academy of Sciences and National Academy of Sciences India. He is also a recipient of the Jean D'Alembert Senior Fellowship, Paris-Saclay University, France, Chemical Research Society of India Medal and Excellence in Teaching Award at IIT Bombay. He has supervised over 25 PhDs and co-authored nearly 200 publications (h-index 49) including four chapters and two books and is also a co-inventor of 6 patents. One of the books he co-authored is the third edition of “Organic Synthesis Based on Name Reactions” with Alfred Hassner. Namboothiri has been a visiting professor at Alternative Energy and Atomic Energy Commission (CEA), Saclay, France and Federal University of Minas Gerais, Belo Horizonte, Brazil. He has delivered over 240 invited lectures at various symposia/conferences and special seminars in India and abroad. Currently, he is an Associate Editor of Journal of Chemical Sciences, Bangalore and is on the editorial board of Journal of Heterocyclic Chemistry. He also serves on several academic and research advisory committees in India.

Rearrangement Reaction Aromatic Tritylation Ketone Oxidation Arylpyridine synthesis N-Heterocycle Amination Indolizine Synthesis Cyclohexene Synthesis Reaction Asymmetric Methylenation Reagent Alkylation Acylation Carbonylation Reagents Bromination Grignard Reagent Asymmetric Epoxidation Allylation Ce Reducing Agent Aminomethylation Addition C-C Cross Coupling Oxidation Cyclopentenone Annulation Chromone Quinoline Oxazole Asymmetric Epoxidation C-C Coupling Allylation; UGI Multicomponent Condensation Reagent Olefin Synthesis Lactonization Cyclohexadienone Synthesis