Synthesis, Organization and Structural Studies of Peptide Motifs Interacting with Membrane Systems - Philipp E Schneggenburger

Synthesis, Organization and Structural Studies of Peptide Motifs Interacting with Membrane Systems

Dissertation
Buch | Softcover
220 Seiten
2010 | 1., Auflage
Books on Demand (Verlag)
978-3-8391-6712-0 (ISBN)
19,99 inkl. MwSt
  • Titel ist leider vergriffen;
    keine Neuauflage
  • Artikel merken
Proteins in biological membranes represent up to 30% of all proteins in sequenced genomes. While certain membrane proteins are functional as monomers others need to assemble into oligomeric structures to carry out their biochemical role. Due to the complexity and dynamics of these interactions, they are often hardly traceable and nearly impossible to predict. For this respect, peptide model systems provide a valuable tool in studying membrane associated processes, since they are synthetically accessible and can be readily modified. Herein, the design and synthesis of peptide/peptide nucleic acid (PNA) conjugates as well as their functional analyses in lipid complexes are reported. The respective species exhibit a high-affinity recognition in the membrane adjacent water layers prior to assembly of the transmembrane domains. Analytical studies of the novel model system include X-ray scattering and Förster resonance energy transfer assays.

Philipp E. Schneggenburger studied chemistry at the Humboldt University of Berlin and at the Georg-August-University Göttingen. After obtaining his diploma degree in the group of Professor Diederichsen (Göttingen) in 2006 he continued his synthetical and biophysical studies of artificial peptide species and their interaction with model membrane systems. He received his doctoral degree with the presented work in 2010.

Sprache englisch
Maße 148 x 210 mm
Gewicht 324 g
Einbandart Paperback
Themenwelt Naturwissenschaften Chemie
Schlagworte Hardcover, Softcover / Chemie/Sonstiges
ISBN-10 3-8391-6712-4 / 3839167124
ISBN-13 978-3-8391-6712-0 / 9783839167120
Zustand Neuware
Haben Sie eine Frage zum Produkt?
Mehr entdecken
aus dem Bereich