Cancer Susceptibility

Identifying Cancer Susceptibility Genes.- The Identification of Colon Cancer Susceptibility Genes by Using Genome-Wide Scans.- Prioritizing Candidate Genetic Modifiers of BRCA1 and BRCA2 Using a Combinatorial Analysis of Global Expression and Polymorphism Association Studies of Breast Cancer.- Microarray-Based Comparative Genomic Hybridization (Array-CGH) as a Useful Tool for Identifying Genes Involved in Glioblastoma (GB).- Multiplex Amplifiable Probe Hybridization (MAPH) Methodology as an Alternative to Comparative Genomic Hybridization (CGH).- Utilizing Saccharomyces Cerevisiae to Identify Aneuploidy and Cancer Susceptibility Genes.- Computational Identification of Cancer Susceptibility Loci.- Digital Candidate Gene Approach (DigiCGA) for Identification of Cancer Genes.- Screening Cancer Susceptibility Genes.- The Use of Denaturing High Performance Liquid Chromatography (DHPLC) for Mutation Scanning of Hereditary Cancer Genes.- Enhanced Mismatch Mutation Analysis: Simultaneous Detection of Point Mutations and Large Scale Rearrangements by Capillary Electrophoresis, Application to BRCA1 and BRCA2.- Economical Protocol for Combined Single-Strand Conformation Polymorphism and Heteroduplex Analysis on a Standard Capillary Electrophoresis Apparatus.- Mutational Screening of hMLH1 and hMSH2 that Confer Inherited Colorectal Cancer Susceptibility Using Denature Gradient Gel Electrophoresis (DGGE).- s-RT-MELT: A Novel Technology for Mutation Screening.- Zoom-In Array Comparative Genomic Hybridization (aCGH) to Detect Germline Rearrangements in Cancer Susceptibility Genes.- Development of a Scoring System to Screen for BRCA1/2 Mutations.- Use of Splicing Reporter Minigene Assay to Evaluate the Effect on Splicing of Unclassified Genetic Variants.- Functional Analysis of Human BRCA2 Variants Using a Mouse Embryonic Stem Cell-Based Assay.- Developing Functional Assays for BRCA1 Unclassified Variants.