Dynamic Combinatorial Chemistry

Joost Reek received his PhD in 1996 under Prof. R.J.M. Nolte in the field of supramolecular chemistry. Following this, he joined Prof. M.J. Crossley?s group in Sydney as a postdoctoral fellow, where he gained experience in porphyrin chemistry and Dendrimers. In 1998 he became a lecturer in the group headed by Prof. P.W.N.M. Van Leeuwen with research activities focusing on transition metal catalysis, and during this period began his own line of research into Supramolecular transition metal chemistry. He has received numerous grants, including the prestigious VICI grant, and in 2005 became a member of the young Royal Netherlands Academy of Arts and Sciences (KNAW). One year later he was appointed full professor at the University of Amsterdam. Dr. Reek currently heads a research group of about 30 people, comprising 18 PhD students and 8 postdocs, working on various topics related to supramolecular chemistry and transition metal catalysis. Sijbren Otto received his Ph.D. degree in physical organic chemistry from the University of Groningen in the Netherlands in the group of Prof. Jan B.F.N. Engberts. After one year in the United States as a postdoctoral researcher with Prof. Steven L. Regen (Lehigh University, Bethlehem, Pennsylvania) he received a Marie Curie Fellowship and moved to the University of Cambridge, where he worked for two years with Prof. Jeremy K.M. Sanders on dynamic combinatorial libraries. He started his independent research career in 2001 as a Royal Society University Research Fellow in Cambridge. In 2009 he moved to the University of Groningen in the Netherlands where he is associated with the newly created Centre for Systems Chemistry.

HISTORY AND PRINCIPLES OF DYNAMIC COMBINATORIAL CHEMISTRY
Introduction
History
Exercising Control over a DCL to Influence Species Distribution
Designing a Dynamic Combinatorial System
Conclusions
THE PRACTICE OF DYNAMIC COMBINATORIAL LIBRARIES: ANALYTICAL CHEMISTRY, EXPERIMENTAL DESIGN, AND DATA ANALYSIS
Introduction
Analytical Methods
Experimental Design
Data Analysis
Conclusions
DEVELOPMENT OF SYNTHETIC RECEPTORS USING DYNAMIC COMBINATORIAL CHEMISTRY
Introduction
Experimental Considerations
Selected Examples
Conclusion
DYNAMIC COMBINATORIAL CHEMISTRY FOR CATALYTIC APPLICATIONS
Introduction
Dynamic Combinatorial Approaches to Cage Catalysts
Dynamic Combinatorial Approaches to Transition Metal Catalysts
Conclusions
DYNAMIC COMBINATORIAL CHEMISTRY: LIGANDS FOR BIOMOLECULES
Ligand Discovery
DCC Strategies in Targeting Biological Systems
Dynamic Diversity Generation for Biological Systems
Applications of DCC in Biological Systems
Conclusions and Future Prospects
POLYMERS FORMED BY DYNAMIC COMBINATORIAL CHEMISTRY
Introduction
Dynamics in Polymers
Biasing Composition by Molecular Recognition
Conclusions and Outlook
ANALYTICAL APPLICATIONS OF DYNAMIC COMBINATORIAL CHEMISTRY
Introduction
Fluorescent Sensors
Colorimetric Sensors
Molecular Timers
Conclusions
TRENDS AND PERSPECTIVES
Introduction
Dynamic Combinatorial Libraries as Molecular Networks
Perspectives